نتایج جستجو برای Thioacetamide

تعداد نتایج: 435  

Journal: :Gut 2001
M E Caballero, J Berlanga, D Ramirez, P Lopez-Saura, R Gozalez, D N Floyd, T Marchbank, R J Playford,

BACKGROUND Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxious agent thioacetamide (TAA). METHODS Mice (20 per group) were fasted overni...

Journal: :The Journal of nutrition 2002
María José Pérez, Antonio Suárez, Jose Antonio Gómez-Capilla, Fermín Sánchez-Medina, Angel Gil,

Dietary nucleotides reportedly promote functionality and repair in fibrotic liver. Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, which lead to the impairment of the hepatic function. The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleo...

Journal: :Molecules 2011
Mirandeli Bautista, David Andres, María Cascales, José A Morales-González, María Isabel Sánchez-Reus, Eduardo Madrigal-Santillán, Carmen Valadez-Vega, Tomas Fregoso-Aguilar, Jorge Alberto Mendoza-Pérez, José Gutiérrez-Salinas, Jaime Esquivel-Soto,

It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell cycle and postnecrotic liver regeneration induced by thioacetamide (TA) in rats was studied. Two months male rats, intraveously pretreated with a single dose of GD (0.1 mmol/Kg), were intraperitoneally injecte...

Journal: :World journal of gastroenterology 2005
Sabrina Fan, Ching-Feng Weng,

AIM To investigate the effects of cyclosporine A (CsA) on thioacetamide (TAA)-induced liver injury. METHODS CsA was co-administrated (7.5 microg/kg body weight per day, i.p.) into rat to investigate the role of CsA on TAA-(200 mg/kg body weight per 3 d for 30 d, i.p.)induced liver injury. RESULTS The data show that TAA caused liver fibrosis in rat after 30 d of treatment. CsA alleviates the...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2005
Jaya Chilakapati, Kartik Shankar, Midhun C Korrapati, Ronald A Hill, Harihara M Mehendale,

Thioacetamide (TA), a potent centrilobular hepatotoxicant, undergoes a two-step bioactivation mediated by microsomal CYP2E1 to TA sulfoxide (TASO), and further to TA-S,S-dioxide (TASO2), a reactive metabolite that initiates cellular necrosis. Our earlier studies showed that bioactivation-mediated liver injury of TA is not dose-proportional. The objective of this study was to examine whether inc...

Journal: :Acta crystallographica. Section C, Crystal structure communications 2004
Fang Fang Jian, Hai Lian Xiao, Yong Qi Qin, Liang Zhong Xu,

In the two title compounds, C17H14N4OS, (I), and C18H16N4O2S, (II), the dihedral angles between the planes of the triazole and N-phenyl rings and the plane of five of the atoms that link these two rings are 63.5 (8) and 73.2 (6) degrees for (I), and 65.1 (1) and 72.1 (3) degrees for (II), respectively. There are some inter- and intramolecular interactions in the crystal structure.

2013
Makoto Shirai, Shingo Arakawa, Hiroaki Miida, Takuya Matsuyama, Junzo Kinoshita, Toshihiko Makino, Kiyonori Kai, Munehiro Teranishi,

To assess modification of thioacetamide-induced hepatotoxicity in mice fed a high-fat diet, male C57BL/6J mice were fed a normal rodent diet or a high-fat diet for 8 weeks and then treated once intraperitoneally with thioacetamide at 50 mg/kg body weight. At 24 and 48 hours after administration, massive centrilobular hepatocellular necrosis was observed in mice fed the normal rodent diet, while...

Journal: :Tissue & cell 2013
H N Mustafa, Sally A El Awdan, Gehan A Hegazy,

Thioacetamide (TAA) has been used in development of animal models of acute hepatic encephalopathy (AHE). This experimental study was designed to evaluate effects of oral administration of vitamin C, vitamin E and their combination on liver and brain enzymes and their histologic and ultrastructure changes. Eighty Wistar rats were included and divided into five groups (16 each). Group 1 (control)...

2011
Farkaad A. Kadir, Faizah Othman, Mahmood Ameen Abdulla, Farida Hussan, Pouya Hassandarvish,

OBJECTIVES This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. MATERIALS AND METHODS The extract was gavaged daily to the rats, at doses of 100 and 200 mg/kg along with thioacetamide at a dose of 200 mg/kg twice weekly. To assess the effectivity of extract...

Journal: :Arquivos de neuro-psiquiatria 2010
Aline Silva de Miranda, David Henrique Rodrigues, Luciene Bruno Vieira, Cristiano Xavier Lima, Milene Alvarenga Rachid, Paula Vieira Teixeira Vidigal, Marcus Vinicius Gomez, Helton José Dos Reis, Cristina Guatimosim, Antônio Lúcio Teixeira,

OBJECTIVE Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA) in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in neurotransmitter release. METHOD HE was induced by an intraperitoneal single dose of TAA (200 mg/k...

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