Serum thyroid hormone and TSH concentrations were measured before and after the administration of TRH (10 micrograms/kg body weight) and bovine TSH (10 IU) in 14 children with chronic lymphocytic thyroiditis. The TRH test showed that the responsiveness of TSH was positively correlated with the basal TSH (P less than 0.001) and inversely with the increase in serum thyroid hormones, for delta T3 ...
:Hong Kong medical journal = Xianggang yi xue za zhi2005
A P S Kong,
C W Lam,
A O K Chan,
S F Yiu,
S C Tiu,
The combination of elevated serum levels of free thyroid hormones with non-suppressed thyroid-stimulating hormone suggests the differential diagnoses of resistance to thyroid hormone or thyroid-stimulating hormone-secreting pituitary tumour. Clinical differentiation of these two conditions can be difficult, because patients with thyroid hormone resistance may exhibit various combinations of hyp...
:Molecular and cellular endocrinology2005
R Thomas Zoeller,
Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by di...
:Nihon eiseigaku zasshi. Japanese journal of hygiene1991
To investigate the effects of whole-body microwave exposure on plasma adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), thyroxine (T4) and free triiodothyronine (T3) levels, rats weighing 267-306 g (light group) and 352-387 g (heavy group) were exposed to microwaves with a frequency of 2,450 MHz at the power densities of 5 and 10 mW/cm2 under an ambient temperature of 21 de...
Gadolinium (Gd)-based contrast agents (GBCAs) are used in diagnostic imaging to enhance the quality of magnetic resonance imaging or angiography. After intravenous injection, GBCAs can accumulate in the brain. Thyroid hormones (THs) are critical for the development and functional maintenance of the central nervous system. TH actions in brain are mainly exerted through nuclear TH receptors (TRs)...
Fredric E. Wondisford,
Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly linked to one of the two thyroid hormone receptor genes, c-erbA,8, in a single kindred, A. We now show that in two other kindreds, B and D, with differing phenotypes, there is also linkage between c-erbAft and GTHR. The combined maximum logarithm of the odds score fo...
The response to an intravenous dose of 200 microng of thyrotrophin releasing hormone (TRH) has been studied by estimating, by radioimmunoassay, baseline levels followed by further estimations of thyroid stimulating hormone (TSH) 20 minutes after the injection and triiodothyronine (T3) three hours after the injection in 112 patients referred for routine thyroid assessment. Comparison of diagnost...
Ana Carolina Dias,
Carolina Maria Módulo,
Angélica Gobbi Jorge,
Alexandre Martins Braz,
Alceu A Jordão,
Rubens Bertazolli Filho,
Jayter Silva de Paula,
Eduardo Melani Rocha,
Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG of rats with hypothyroidism and in controls and to evaluate the impact of th...
Eva K Wirth,
Marc O Klein,
LAT2 (system L amino acid transporter 2) is composed of the subunits Slc7a8/Lat2 and Slc3a2/4F2hc. This transporter is highly expressed along the basolateral membranes of absorptive epithelia in kidney and small intestine, but is also abundant in the brain. Lat2 is an energy-independent exchanger of neutral amino acids, and was shown to transport thyroid hormones. We report in the present paper...
:Arquivos brasileiros de endocrinologia e metabologia2008
Monalisa Ferreira Azevedo,
Gustavo Barcelos Barra,
Ligiane Dantas de Medeiros,
Luiz Alberto Simeoni,
Luciana Ansaneli Naves,
Francisco de A Rocha Neves,
Resistance to thyroid hormone (RTH) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (TRbeta). We describe a large Brazilian family harboring a novel mutation affecting TRbeta gene and inducing RTH. A 14-year-old girl was found to have elevated free T4 and free T3 plasma concentrations in ...