Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TR beta) gene. We recently treated a 38-yr-old woman with RTH who had incidental papillary thyroid carcinoma. She presented with goiter and displayed ...

Thyroid disorders are known to involve all the organ systems of the body and the skin is no exception. Some dermatological skin findings and diseases may be the first symptoms of thyroid disease [1]. Available data suggest that thyroid hormone plays a pivotal role in embryonic development of mammalian skin as well as in maintenance of normal cutaneous function an adult skin. Thyroid hormone sti...

INTRODUCTION Prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (TSH). This condition is labeled "low 3,5,3'-tri-iodothyronine (T3) syndrome" or "nonthyroidal illness syndrome (NTI)" or "euthyroid sick syndrome". Despite the low circulating and peripheral tissue thyroid hormone levels, thyrotropin releasing hormone (TRH)...

Frog metamorphosis has long been a fascinating example of thyroid hormone actions on development (1), and insights gained from studies of frog metamorphosis are helping us understand the role of thyroid hormone in the development of a completely different tissue—the human brain. In frogs such as Xenopus laevis, thyroid hormone controls the dramatic transformation from the larval to the adult fo...

Thyroid hormones play essential roles in mammalian life, especially in neurodevelopment (Porterfield & Hendrich, 1993). This fact is clearly shown in patients with neurological deficits from endemic cretinism, who reside in iodine-deficient areas (DeLong et at., 1985). In addition to neurological impairments, thyroid dysfunctions, such as hyperthyroidism and hypothyroidism, lead to a wide varie...

In a screening programme for neonatal hypothyroidism an otherwise healthy female infant was found to have a high concentration of thyroid stimulating hormone in a filter paper blood spot and in serum. A high concentration was also found in the maternal serum. Mother and baby were both biochemically euthyroid with normal serum thyroxine concentrations. The apparently high concentration of thyroi...

Introduction: Fasting during the holy month of Ramadan is an obligation for all adult, healthy Muslims. As several studies have indicated, both fasting and energy restriction can alter thyroid hormone metabolism and affect the clinical features and well-being of hypothyroid patients. Hypothyroidism is more prevalent among women and the elderly. Its prevalence has been reported to be 4-8% of the...