:Journal of nutritional science and vitaminology1977
The platelets of vitamin E-deficient rats show a remarkable structural destruction of the mitochondria, mainly in the membrane, and a considerable decrease in the number of mitochondria. In addition, significant decreases are manifested in the numbers of microtubules, alpha-granulomers, dense bodies and glycogen particles, accompanied by remarkable vacuole formation. The longer the vitamin E-de...
:Asia Pacific journal of clinical nutrition2002
Cardiovascular disease, in particular coronary artery disease (CAD), remains the most important cause of morbidity and mortality in developed countries and, in the near future, more so in the developing world. Atherosclerotic plaque formation is the underlying basis for CAD. Growth of the plaque leads to coronary stenosis, causing a progressive decrease in blood flow that results in angina pect...
Ischemic heart disease (IHD) has now assumed a global dimension. It still remains one of the major health problems not only in the advanced countries, but also, is becoming a serious health issue in the developing and the economically weaker countries. Apart from other factors, changing economic scenario, stress and strain in daily life as well as altered dietary habits in the populations appea...
The creatinuria of rabbits maintained on the diet of Goettsch and Pappenheimer (l), which was first reported by Morgulis and Spencer (2), has been considered by most investigators to be the earliest detectable sign of nutritional muscular dystrophy. Increased urinary excretion of creatine usually is observed in vitamin E-deficient rabbits several days before the appearance of the physical signs...
The aim of this work was to study the influence of vitamin E (2mM) on capacitation and acrosome reaction of crossbred cattle bull spermatozoa. Fresh semen suspended in TALP medium (pH 7.4) was divided into four equal fractions. All fractions; control (containing TALP + spermatozoa) and the experimental [treated / untreated with ferrous ascorbate (FeAA – 150 μM FeSO4 : 750 μM ascorbic acid); sup...
D A Butterfield,
α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the α-tocopherol transfer protein for the murine version (Ttpa(-/)(-)) mice which lack the α-to...
:The Malaysian journal of medical sciences : MJMS2002
Nafeeza Mohd Ismail,
Ahmad Asmadi Yusof,
Cigarette smoke contains numerous oxygen free radicals that when inhaled, overwhelm antioxidant defenses and produce a condition of oxidative stress. This study investigated whether or not supplementation with vitamin E can affect the state of oxidative stress in healthy smokers. In this randomised double blind trial, 32 smokers received 200 mg of vitamin E or placebo daily for 8 weeks. All smo...
V E Kagan,
E A Serbinova,
Oxidative modification of low density lipoproteins (LDL) and their unrestricted scavenger receptor-dependent uptake is believed to account for cholesterol deposition in macrophage-derived foam cells. It has been suggested that vitamin E that is transported by LDL plays a critical role in protecting against LDL oxidation. We hypothesize that the maintenance of sufficiently high vitamin E concent...
Martha Clare Morris,
Denis A Evans,
Julia L Bienias,
Christine C Tangney,
Robert S Wilson,
Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases.
To examine whether intake of antioxidant nutrients, including vitamin E, vitamin C, and carotene, is associated with reduced cognitive decline with age.
Longitudinal population-based study conducted from September 17, 1993, to November 20, 2000, with an average fo...