Formation of syncytial muscle fibers involves repeated rounds of cell fusion between growing myotubes and neighboring myoblasts. We have established that Wsp, the Drosophila homolog of the WASp family of microfilament nucleation-promoting factors, is an essential facilitator of myoblast fusion in Drosophila embryos. D-WIP, a homolog of the conserved Verprolin/WASp Interacting Protein family of ...

The steelmaking process consists of two phases: primary steelmaking and finishing lines. The scheduling of the continuous galvanizing lines (CGL) is regarded as the most difficult process among the finishing lines due to its multi-objective and highlyconstrained nature. In this paper, we present a multi-population parallel genetic algorithm (MPGA) with a new genetic representation called k near...

The aim of this paper is to approach the design of distributed layouts for lower work-in-process (WIP) levels. Traditionally, the design of manufacturing layouts has considered as objective the minimization of the material handling cost. Alternatively, distributed layouts are claimed to have good performance under volatile environments, though it has been little investigated how these layouts b...

Abstract Concept mapping facilitates the externalisation and internalisation of knowledge by individuals during collaborative construction. However, not much is known about individual learning processes concept (CCM) in interdisciplinary Premised on literature collaboration scripts to scaffold process, this study investigates effect an preparation phase prior work epistemic social co-constructi...

We consider single and multiple part type production lines and networks with ®nite bu€ers and unreliable machines. Three fuzzy control modules, namely, line, assembly, and disassembly controller, are developed. The objective is to keep the work-in-process (WIP) inventory and cycle time at low levels, along with high machine utilization and throughput. This is achieved by adjusting the processin...

Myosin 1E (Myo1E) is recruited to sites of clathrin-mediated endocytosis coincident with a burst of actin assembly. The recruitment dynamics and lifetime of Myo1E are similar to those of tagged actin polymerization regulatory proteins. Like inhibition of actin assembly, depletion of Myo1E causes reduced transferrin endocytosis and a significant delay in transferrin trafficking to perinuclear co...

The production planning problem, that is, to determine the production rate of a factory in the future, requires an aggregate model for the production flow through a factory. The canonical model is the clearing function model based on the assumption that the local production rate instantaneously adjusts to the one given by the equilibrium relationship between production rate (flux) and work in p...

POMS 22 nd Annual Conference Reno, Nevada, U.S.A. April 29 to May 2, 2011 Abstract: MTS-MTO system is suitable where standard modules are shared by various finished products through divergent finalization. The system can satisfy product variety by taking advantage of flexibility of MTO, but its performance is lowered when the capacity is constrained. One way of dealing with the problem without ...

Abstract Modern market scenarios are imposing a radical change in the production concept, driving companies’ attention to customer satisfaction through increased product customization and quick response strategies maintain competitiveness. At same time, growing development of Industry 4.0 technologies made possible creation new manufacturing paradigms which an level autonomy is one key concepts...