The WASP-interacting protein (WIP) targets WASP/WAVE proteins through a constitutive interaction with an amino-terminal enabled/VASP homology (EVH1) domain. Parallel investigations had previously identified two distinct N-WASP binding motifs corresponding to WIP residues 451-461 and 461-485, and we determined the structure of a complex between WIP-(461-485) and the N-WASP EVH1 domain (Volkman, ...

Variability in construction projects usually leads to schedule delays, cost overruns and productivity losses. Among the different techniques and tools employed to manage a construction project the use of buffers is a common approach to handle variability and to protect production processes from its negative impact. Time float, resource inventories and budget contingencies are examples of buffer...

We develop a constant time interval production planning and control methodology, called CONSTIN, and its associated simulation system for a large-scale and unstable semiconductor manufacturing process. CONSTIN moves work-in-process inventories (WIP) between processes only at a constant time interval, and consequently maintains a desirable level of WIP. Our theoretical and experimental analysis ...

This article presents a simulation study over a small supply chain, where the amount of work-in-process (WIP) is restricted. The supply chain consists of five linked machines, or production facilities, with stochastic operation times. A number of test cases are made where the number of jobs in the machines and the buffer areas are restricted. The restrictions are designed both in the Kanban way...

Under the modern discrete manufacturing mode, the multi-variety and small-batch production system satisfies the requirements of the diversified demands of consumers, rapid responses to market needs and high core competitive advantages. Especially, in this production system, tightly coupled cells are widely applied to improve production flexibility and precision and reduce manufacturing costs. H...

Extended Fer-CIP4 homology (EFC)/FCH-BAR (F-BAR) domains generate and bind to tubular membrane structures of defined diameters that are involved in the formation and fission of endocytotic vesicles. Formin-binding protein 17 (FBP17) and Toca-1 contain EFC/F-BAR domains and bind to neural Wiskott-Aldrich syndrome protein (N-WASP), which links phosphatidylinositol (4,5)-bisphosphate (PIP(2)) and ...

In this paper, we study five aspects of design for wheeled inverted pendulum (WIP) platforms with the aim of understanding the effect of design choices on the balancing performance. First, we demonstrate analytically and experimentally the effect of soft visco-elastic tires on a WIP showing that the use of soft tires enhances balancing performance. Next, we study the effect of pitch rate and wh...

The Wiskott-Aldrich syndrome (WAS) interacting protein (WIP) stabilizes the WAS protein (WASP), the product of the gene mutated in WAS. WIP-deficient T cells have low WASP levels, limiting the usefulness of WIP KO mice in defining the role of WIP in T cell function. To define this role, we compared WIP/WASP double KO (DKO) mice to WASP KO mice on DO11.10 background. T cell development was norma...