Background: The natural history of immunoglobulin (Ig) E-mediated diseases in preterm infants is still elusive. We aimed at developing a non-invasive tool for detecting specific IgE (sIgE) and eosinophil-derived neurotoxin (EDN) neonatal fecal samples evaluating its predictive value the development IgE-mediated during first year life. Methods: developed stool extraction protocol, followed by fr...

Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnosti...

The topic of morphological productivity as it has been conceived in linguistics for the last half-century is treated in greatest detail in Bauer (2001). If our brief discussion here leads the reader to that book, we will have gone a long way to doing our job. In this chapter, though, we also have a different aim, which is to recast the problem of morphological productivity in a different light....

Homes cannot be made allergen free, but exposure to the major indoor allergens can be reduced. All reduction recommendations are based on the principle of reducing or isolating the source, and certain recommendations can be made on the basis of published evidence. House dust mite avoidance measures include fitting allergen-proof mattress and pillow encasings, washing bedding regularly, and redu...

Allergen immunotherapy was introduced by Leonard Noon 100 years ago and is the only disease-modifying treatment for allergic individuals. Improved understanding of immunology has taught us a great deal about the underlying mechanisms involved in allergen immunotherapy; however, despite these developments, a number of important questions remain unanswered. Several of these questions relate to th...

Critical aspects of formulating allergy immunotherapy vaccines include the selection, total number, and proportions of each allergen component in therapeutic mixtures. The immunotherapy prescription, determined by a medical provider, details the dosing and schedule for treatment as well as the specific composition of the treatment vials. Allergen extracts are composed of many components such as...

BACKGROUND Exposure of patients with atopic asthma to allergens produces a long term increase in exhaled nitric oxide (FENO), probably reflecting inducible NO synthase (NOS) expression. In contrast, bradykinin (BK) rapidly reduces FENO. It is unknown whether BK suppresses increased FENO production after allergen exposure in asthma, and whether it modulates FENO via NOS inhibition. METHODS Lev...

background: there are many therapeutic methods for allergic conditions. cpg oli-gonucleotides play a critical role in immunity via the augmentation of th1 and suppres-sion of th2 responses. objective: in the present study we aimed to estimate the effec-tiveness of intranasal administration of cpg odn plus chenopodium album allergen in allergic asthma compared with the administration of allergen...

Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials and methods: Four hundreds and one patients with a clinical diagn...