The Department of Oto-Rhino-Laryngology, Tokyo Medical and Dental University, School of Medicine (Director: Prof. Isamu Watanabe) Although the concentration of the japanese cedar specific IgE antibody in blood can be measured with RAST, the Phadebas RAST Kit contains no japanese cedar allergen disc. Japanese cedar allergen disc (I : 20) was newly prepared. It was evaluated whether this japanese...

Background Allergens tend to sensitize simultaneously. Etiology of this phenomenon has been suggested to be allergen cross-reactivity or concurrent exposure. However, little is known about specific allergen sensitization patterns. Objective To investigate the allergen sensitization characteristics according to gender. Methods Multiple allergen simultaneous test (MAST) is widely used as a sc...

BACKGROUND Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. METHODS Wild-type mice were treated wit...

Besides IgE, the Ab isotype that gives rise to sensitization and allergic asthma, the immune response to common inhalant allergens also includes IgG. Increased serum titers of allergen-specific IgG, induced spontaneously or by allergen vaccination, have been implicated in protection against asthma. To verify the interference of topical IgG with the allergen-triggered eosinophilic airway inflamm...

BACKGROUND Bronchoprovocation challenges use direct or indirect acting stimuli to induce airflow obstruction. Indirect stimuli either non-allergic/non-IgE mediated (e.g. exercise, mannitol) or allergic/IgE mediated (i.e. allergen) trigger mast cells to release bronchoconstricting mediators (e.g. cysteinyl leukotrienes, histamine). Performing repeat challenges within a short timeframe (e.g. 3 h)...

Background Allergic rhinitis is one of the most common types of rhinitis. Allergen avoidance is the most important way of preventing this disease. The present study is carried out to determine the frequency of common aeroallergens in patients with allergic rhinitis in Gorgan city by skin prick test (SPT) reactivity. Materials and Methods  In this cross-sectional study 270 patients referring t...