parkinson`s disease (pd) is the second most common neurodegenerative disorder after alzheimer`s disease. it is a chronic and progressive disease, and mostly afflicts elderlies. pd starts with sudden onsets and the exact cause of the disease is still unknown, however there are some early symptoms that can help us to diagnose the disease and ameliorate its effects. pd is a multi-factorial disease...

Background: Coronary artery disease is considered as the most common cause of death in all societies including Iran. This study seeks to compare the new risk factors of coronary-artery diseases in obese adolescents and control group.Methods: In this cross-sectional study, amongst the obese adolescents registered in the nutrition clinic of Ghaem Hospital, 80 individuals were selected. As the con...

Abstract Aims: To investigate the effect of Myrtenol, the active ingredient of Myrtle, on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Methods: Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma+Dexamethasone and Asthma+Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2.5mg/kg) was a...

The free radical oxidants such as reactive oxygen species, nitrogen and sulphur species are produced inside cells through various metabolic processes. body is equipped with an antioxidant defence system that guards against oxidative damage caused by these plays a major role in protecting from stress damage. Costus igneus possess pharmacological activities like hypolipidemic, diuretic, antioxida...

In addition to its traditional role in the regulation of calcium homeostasis and bone metabolism, vitamin D also exhibits immunomodulatory, anti-proliferative and cancer preventive activities. Molecular mechanisms that confer the chemo-preventive properties to vitamin D are poorly understood. We previously reported that constitutive phosphorylation of histone H2AX on Ser139 (γH2AX) and activati...

Exposure of Escherichia coli to H2O2 leads to two kinetically distinguishable modes of killing: mode I killing occurs maximally near 2 mM H2O2, whereas mode II killing is essentially independent of H2O2 concentrations up to 20 mM. A major portion of H2O2 toxicity is attributed to DNA damage caused by the iron-mediated Fenton reaction. By studying DNA damage during Fenton reactions in vitro, the...

few researches have been performed on the circadian rhythm of oxidants and anti-oxidants and these studies have demonstrated different results. the aim of this study was to investigate the circadian variation of mda, pc and sod in non-athlete young men. the research method of this study was semi-experimental. for this purpose, 10 non-athlete active students (mean age: 23.2±2.57 years old, heigh...

Abstract Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving degradation. Nevertheless, early pathogenic events still unclear. To investigate this, we employed an antibody that specific oxidative post-translation...