background and aims. lichen planus is a relatively common chronic mucocutaneaous disease with an unknown cause, and is considered a manifestation of cell-mediated immune response. hepatitis c virus (hcv) and its subgroups have been associated with lichen planus in different geographic locations. the present study was undertaken to evaluate the prevalence of hcv antibody in patients with lichen ...

background: toxoplasmosis is a world wide parasitic disease infecting human by oocyst, tissue cyst or tachyzoites in raw meat, water or congenitally during pregnancy. toxoplasmosis can cause abortion in pregnant women. the current seroepidemiological study was designed to assess toxoplasmosis in pregnant women with or without the history of abortion. methods: in a case–control study the antibod...

alpha-fetoprotein (afp), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. monoclonal anti-afp antibodies are essential reagents in developing appropriate techniques for measurement of this protein. in this study, in order to produce anti-afp monoclonal antibo...

to evaluate the correlation of cytomegalovirus (cmv) and coronary artery disease (cad), one-hundred patients with cad and the same number of healthy individuals as a control group were randomly selected and studied for anti-cmv using elisa method. ninety percent of patients and 77 percent of the control group were anti-cmv positive and statistical analysis showed a significant correlation betwe...

introduction : in order to evaluate the role of thyroid autoimmunity in patients with goiter, this study was done 10 years after implementation of iodine supplementation program ( iodised salt). the serum levels of thyroid peroxidase antibodies (anti tpo) and thyroglobulin antibodies (anti tg) were studied in a group of patients with simple goiter and compared with normal controls. materials an...

objective(s): as t-cell immunoglobulin and mucin domain 3 (tim-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. based on the unique features of nanobodies, we aimed to construct an anti-tim-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. materials and meth...

antibodies provide a suitable tool in fundamental research and their high affinity and specificity make them invaluable for diagnostic and therapeutic applications. a promising alternative to conventional antibodies are the heavy chain antibodies (vhh) of camelidae having short length, high solubility and stability are preferred to other antibody derivatives. in this study, our goal was product...

southern margin of the caspian sea due to keeping of domestic animals and abundance of surface water reservoirs is prone to infection with leptospira sp.. this study was performed to determine anti-leptospira antibody frequency in golestan province, southeast of the caspian sea in the north of iran. this study was performed on 1028 people in golestan province. sampling was stratified. leptospir...

neonatal tetanus (nt) is a leading cause of neonatal mortality in many parts of the world. tetanus is a vaccine-preventable disease and is second only to measles worldwide as a cause of childhood mortality. in this study the various irnrnunoglobulin classes of anti-tetanus antibody in the sera of 105 iranian women of childbearing age (13-45 years) were titrated by enzyme linked immunosorbent as...