background: the autoimmune disease known as idiopathic (immune thrombocytopenic purpura thrombocytopenic purpura (itp) is clinically defined by a low numbers of platelets in the circulation blood. this study aimed to isolate autoantibodies made against the platelet glycoproteins using platelets from healthy volunteers, to determine their specificity and further elucidate their effects on platel...

background: thalassemia patients are more susceptible to hepatitis than the normal population due to the frequent blood transfusions. objective: to determine the immune response of children with major ß-thalassemia, by measuring anti-hepatitis b surface antibody (anti-hbs ab) following the last hbv vaccine injection. methods: this study was carried out on 215 thalassemic children who received t...

abstract background thalassemia patients that are conventionally treated by a regular transfusion regimen are exposed to blood born viral infections.the aim of this study was to investigate the seroprevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) , and human immunodeficiency virus(hiv) among all multitransfused thalassemia patients in west north of iran. material and methods a ret...

background: human cd34 is a transmembrane glycoprotein which is expressed in human hematopoietic stem cells (hscs) and the small- vessel endothelial cells of a variety of tissues. cd34 plays a critical role as a marker for diagnosis and classification of leukemia. anti cd34 antibodies are used for isolation and purification of hscs from bone marrow, peripheral blood and cord blood. objective: t...

Background: Anti-thyroid peroxidase antibody (anti-TPO antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. Objective: To evaluate the relationship between serum levels of anti-TPO ...

chlamydia trachomatis is an obligate intracellular bacterium which causes a wide variety of human infections such as ocular, urogenital and respiratory infections. genital infections of women, espe-cially when repeated, give rise to many complications such as ectopic pregnancy, miscarriage and in fertility. since chlamydial infections are usually asymptomatic, they progress unnoticed and produc...

background: antifertility effect of naturally occuring antisperm antibody (asa) in infertile couples and studies on experimental immunization of various animals with sperm antigens represents asa as immunocontraceptive target. despite extensive research on the effects of different factors on sperm immunogenecity and asa production variable result have been reported. objective: to study whole sp...

background: the major cause of peptic ulcer disease is helicobacter pylori (hp), and it is also implicated in the pathogenesis of adenocarcinoma of the distal stomach and gastric lymphoma. the incidence of peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma are more common in people infected of caga positive strains of hp. the aim of this study was to determine the prevalence o...