BACKGROUND The enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized. METHODOLOGY/PRINCIPAL FINDINGS Here we used the elevated plus maze behavioral paradigm...

Oxytetracycline (OTC) is one of the broad-spectrum antibiotics widely used for treatment fish-farm infection. Considering that behavior directly related to reproduction, individual fitness, and survival, it important evaluate impact on behavioral repertoire in fish. Zebrafish (Danio rerio) presents a well-described reliably demonstrate complex responses chemical compound exposure. This work aim...

Among the numerous consequences of prenatal alcohol exposure (PAE) is an increase in anxiety-like behavior that can prove debilitating to daily functioning. A significant body of literature has linked gestational day 12 (G12) heavy ethanol exposure with social anxiety, evident in adolescent males and females. However, the association between non-social anxiety-like behavior and moderate alcohol...

The corticotropin-releasing factor (CRF) system mediates stress responses. Extrahypothalamic CRF1 receptor activation has anxiogenic-like properties, but anxiety-related functions of CRF2 receptors remain unclear. The present study determined the effects of intracerebroventricular administration of a CRF2 agonist, urocortin 3, on behavior of male Wistar rats in the shock-probe, social interacti...

BACKGROUND AND PURPOSE Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused on incidence rather than outcome. The goal of this study was to determine the effects of prior exposure to chronic stress on ischemia-induced neuronal death, microglial activation, and anxiety-like behavior. METHODS In Experiment 1, mice were exposed to...

Background and Purpose—Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused on incidence rather than outcome. The goal of this study was to determine the effects of prior exposure to chronic stress on ischemia-induced neuronal death, microglial activation, and anxiety-like behavior. Methods—In Experiment 1, mice were exposed to 3...

objective(s) there is well documented evidence for the increase in widespread use of complementary and alternative medicine in the treatment of physical and psychiatric symptoms and disorders within the populations. in the present study, we investigated the influence of vitex agnus-castus (vitex) on anxiety-like behaviors of rats. materials and methods elevated plus maze which is one of the met...

During pregnancy, women with polycystic ovary syndrome (PCOS) display high circulating androgen levels that may affect the fetus and increase the risk of mood disorders in offspring. This study investigated whether maternal androgen excess causes anxiety-like behavior in offspring mimicking anxiety disorders in PCOS. The PCOS phenotype was induced in rats following prenatal androgen (PNA) expos...

objective(s) the effect of testosterone on anxiety-like behaviors has been the subject of some studies. there is evidence that testosterone modulates anxiety via gaba (gama aminobutyric acid) and gabaergic system. the involvement of gabac receptors in those effects of testosterone on anxiety-like behaviors of the rats was investigated in the present study. materials and methods a group of rats ...