background: testosterone level in men decreases with aging (andropause) and androgen deficiency is responsible for a variety of behavioral symptoms such as anxiety. the aim of this study was to investigate the effect of pistacia atlantica (bane) fruit extract on anxiety-like behavior in intact and gonadectomized rats. materials and methods: in this study, adult male rats were divided into two g...

Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body ...

The relationship between anxiety and maternal behavior has been explored across species using a variety of approaches, yet there is no clear consensus on the nature or direction of this relationship. In the current study, we have assessed stable individual differences in anxiety-like behavior in a large cohort (n=57) of female F2 hybrid mice. Using open-field behavior as a continuous and catego...

Tiffany A. Wills: Effects of Repeated Ethanol Withdrawals and Stress/Withdrawal Paradigms in Adolescent Rats (Under the Direction of Dr. George R. Breese) Adolescence is a period of development that is marked with increased vulnerability to the use and abuse of alcohol. Many studies have illustrated that adolescents respond to ethanol in ways that are distinct from adults. The adult literature ...

Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic dorsal raphe nucleus (dRN) of adult rats. Interactions between serotonin and CRF systems are thought to mediate anxiety behavior. Therefore, we invest...