objective(s) cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. this study was performed to determine the effect of daily supplementation of vitamin e on oocytes apoptosis in nicotine-treated mice. materials and methods in this experimental study, 24 nmari adult female mice were randomly allocated into four experimental groups. for...

Introduction: Previous studies have proven that secretory materials of mesenchymal stem cells (MSCs) (secretome) remedial properties. Objectives: The main goal this study was to evaluate the effects secretome adipose-derived MSCs on growth and apoptosis in anaplastic thyroid carcinoma (ATC) C-643 cells. Materials Methods: Initially, were exposed 25 50 μg/mL (ADSCs) for 24 48 hours, proliferatio...

In this study, the antioxidative effect of melatonin was investigated in aging retinal pigment epithelial cells vitro. The objective study is to explore administration pharmacological doses for prevention symptoms.Specific concentrations (20 µM, 40 µM and 80 µM) were used treat hydrogen peroxide-induced flow cytometry employed examine cell apoptosis. A specific probe utilized detect intracellul...

Apoptosis has attracted great attention in the last two decades and number of publications related to apoptosis been growing exponentially. The revolution that occurred research is a direct result better understanding genetic program biochemical mechanisms apoptosis. not only common normal event but also essential for growth development organisms. In adult, mostly abnormal, its absence or failu...

Objectives: We aimed to investigate the neuroprotective effects of linagliptin in an vitro 6-hydroxydopamine (6-OHDA) Parkinson’s disease model. Methods: 6-OHDA (200 µM) were administered SH-SY5Y cells for 24 h induce model vitro. Cells treated with (1, 10, 50 and 100 nM) 30 minutes before administration. Cell viability was examined by 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromi...

The paper aimed to investigate the effects of up-regulation and down-regulation Mir-299-3p on proliferation, migration, invasion apoptosis lung adenocarcinoma cell line H1299, preliminarily explore mechanism regulating biological behavior cells. inhibitor mimics were transfected into transfection efficiency was measured by fluorescence microscopy. successfully cells detected invasion, apoptosis...

background: quantification of radiation-induced apoptosis in peripheral blood lymphocytes (pbls) has been proposed as a possible screening test for cancer-prone individuals and also for the prediction of normal tissue responses after radiotherapy. materials and methods: the neutral version of the comet assay (single-cell gel electrophoresis) was used 24, 48, 72 hours after irradiation with 8 gy...

abstractbackground: radioprotective effects of famotidine, an antagonist of h2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. this study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis in...

Background & Aims: Multiple sclerosis (MS) is one of the chronic autoimmune diseases of the central nervous system with unknown etiology. The present study aimed to investigate the apoptosis and nitric oxide (NO) production of endothelial cells treated with serum of patients with MS and response to interferon beta (IFN- ) therapy. Methods: Human umbilical vein endothelial cells were treated wit...

Objective(s) Cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. This study was performed to determine the effect of daily supplementation of vitamin E on oocytes apoptosis in nicotine-treated mice. Materials and Methods In this experimental study, 24 NMARI adult female mice were randomly allocated into four experimental groups. ...