Introduction: In this study, we explore in detail cell-specific targeting efficacy of nano-photo-thermal therapy (NPTT) method and the resulting responses that are induced by variable laser intensities and exposure times in cancer cells to induce selective apoptosis. We delineate the synthesis of a high-yielding synthetic F-AuNPs by tailoring the surface of gold nanoparticles ...

This study explored the changes in bone marrow CD235a+ nucleated red blood cell apoptosis and signal pathways patients with chronic mountain sickness. We collected data from 21 sickness 20 non-chronic patients. Bone mononuclear cells, flow cytometry is used to detect apoptotic index of cells determine mitochondrial membrane potential; reverse transcription quantitative polymerase chain reaction...

Abstract Background Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate whether SFRP5 could protect chondrocytes against LPS-induced inflammation and apoptosis. Methods ATDC5 cells that overexpressed with or not were challenged LPS observe...

sophora pachycarpa schrenk ex c.a.mey. belongs to the family fabaceae. some species of the genus sophora have shown to possess anti-proliferative and apoptosis-inducing activites in cancer cells. however, there is no available information addressing this effect in s. pachycarpa. here, we investigated the cytotoxic effects of methanol extract and different fractions obtained from s. pachycarpa r...

despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. in present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

objective: it is a firm belief that blood transfusion is life-saving in many situations, but at the same time transfusion complications could be life-threatening. the possible effects of blood transfusion related immunomodulatory (trim) and its related mechanisms is one of the important debatable subjects in the field of blood transfusion medicine. one of the mechanisms through which transfus...

objective: leishmaniasis is one of the significant causes of morbidity and mortality in several countries. it is an important problem in endemic areas such as iran. the goal in treatment of leishmaniasis is to reduce the disease period and leave no evidence of any remaining scars or lesions. a derivative of artemisinin is artemether. scientists believe that the strong action of artemether again...

objective: the goals of the study are evaluation the effect(s) of food deprivation as a social stress on testis structure. we also investigated the effects of melatonin treatment as an antioxidant component and inequality on the effect(s) of food deprivation. methods: we investigated the improving effects of melatonin and social stress (food deprivation) on 42 male rats in 7 groups including co...

objective: this study was to evaluate the effect of vitamin c on the histology and histochemistry of the prefrontal cortex of ethanol-induced rats. methods: male sprague-dawley rats were used for the study. ethical approval was obtained from the university’s ethical committee. the rats were randomly divided into 6 groups of 10 rats each. rats in group a= free access to normal saline. rats in gr...

objective: scutellaria (lamiaceae) has been implicated for medicinal purposes both in modern and traditional medicine. some species of the genus scutellaria has extensively been studied for anticancer activity. scutellaria luteo-coerulea (s. luteo-coerulea) is one of the iranian species of the genus scutellaria. materials and methods: in the present study, cytotoxic and apoptogenic properties o...