results the mean number and size of betz cells in the stressed group decreased significantly compared to those in the control group (p < 0.05). qualitative observations revealed chromatolysis of nissl bodies, nucleus condensation, and a decrease in neural processes. the mean number of apoptotic cells in the stressed group were also significantly increased compared to that of the control group (...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide which can lead to pathological effects in mammals through oxidative stress. on the other hand, virgin olive oil (voo) is a rich source of phenolic compounds with antioxidants. the aim of the present study was to determine the protective effects of voo against dm-induced hepatotoxicity. methods: thirty-six mice were randomly sep...

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

background: regarding the strong differentiation and anti-leukemic activity of dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. the aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using u937 cells. met...

background: alzheimer’s disease (ad) is a progressive neurodegenerative disease and nowadays the role of endothelial cell (ec) injury has been proposed in pathological process in ad. peroxisome proliferator‑activated receptor‑γ (ppar‑γ) agonist has anti‑inflammatory properties through activation in glial cells and improves vascular function and prevent atherosclerotic disease progression. the a...

introduction: neurotrophins belong to growth factor family and their function is based on their receptors. they bind two types of receptors: p75 and tyrosine kinase. the motoneuron survival or death depends upon the neurotrophic factors. recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. deprenyl or selegiline is known as a drug with neuroprotecti...

objective(s):silver nanoparticles (ag-nps) are used widely in bedding, water purification, tooth paste and toys. these nanoparticles can enter into the body and move into the hippocampus. the aim of this study was to investigate the neurotoxicity of silver nanoparticles in the adult rat hippocampus. materials and methods:12 male wistar rats were randomly divided into two experimental and contro...

objective(s): pesticides has wide range of infertility in female reproductive. this study was done to evaluate the effect of movento pesticide on development of granulosa cells and ovarian follicles and foxo1 and vnn1 gene expression in balb/c mice. materials and methods: in this study 40 healthy balb/c mice 5-6 weeks age were used. animals were randomly allocated into four groups. control (wit...

objective(s):ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. lung damage induced by ischemia/reperfusion (i/r) is a frequent problem in lung transpl...

methods s. cerevisiae was cultured and then disrupted by sonication. after centrifugation, the harvested supernatant was considered to be a cytoplasmic extract. the protein concentration was determined by the biuret method and the extract was diluted to concentrations of 500, 1000, and 2000 µg protein/ml. the frequencies of apoptosis and necrosis were assessed in extract-treated k562 cells by e...