background: saccharin is an artificial non-caloric sweetener that used to sweeten products such as drinks, candies, medicines, and toothpaste, but our bodies cannot metabolize it. sodium saccharin is considered as an important factor in tumor promotion in male rats but not in humans. objective: the objective of this study was to investigate the effect of saccharin consumption on sperm parameter...

Apoptosis is a programmed cell death mechanism, with its presence and absence, directs the progression of most diseases targeted in disease treatments. Many factors are influential cell's pathway to apoptosis. The defects these pathways may transform become malignant, organism face lethal outcome such as cancer. Understanding apoptosis will provide clues guiding pathogenesis diseases. Two main ...

Apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. It is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. Pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

background: more than 40% of infertilities are due to endometriosis. ultrustructural and histochemical study of endometrium will help to clarify the etiology of endometriosis. objective: the aim of the present study was to investigate the ultrastructure and occurrence of apoptosis in endometrial cells of women with or without endometriosis. materials and methods: in the present case-control stu...

objective(s):the aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. materials and methods: fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (n.s) group; 30 mg/kg of n.s treated via gavage. 2- control (c) group, administrated with distilled water via gavage....

objective(s) the effect of berberis vulgaris aqueous extract in hepatocarcinogenic rats was studied to investigate the apoptotic and sodium, potassium elements properties. a loss of both intracellular potassium and sodiumoccurs when apoptotic cells shrink and prior to the loss of membraneintegrity. materials and methods forty-eight sprague dawley rats were randomly divided into 2 groups, normal...

objective(s) doxorubicin (dox), a widely used chemotherapeutic agent can give rise to serve cardiotoxicity by inducing apoptosis. curcumin, the active compound of the rhizome of curcuma longa l. has anti-inflammatory, antioxidant and anti-proliferative activities. curcumin has been identified to increase cytotoxicity in several cancer cell lines in combination with dox, but there is no study ab...

objective(s): 3,4-methylenedioxymethamphetamine (mdma) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in  liver cells. the present study aimed to investigate the effects of pentoxifylline (ptx) on liver damage induced by acute administration of mdma in wistar rat. materials and methods: animals were administered with...

introduction: acrylamide (acr) known as a neurotoxic agent in human and animals. previous studies have been shown; fasudil improves neurological deficit and neuronal damage. in this study, the effect of fasudil, potent rho-kinase inhibitor, on acr-induced cytotoxicity was evaluated using pc12 cells as a suitable in vitro model. materials and methods: pc12 cells were exposed to different concent...

recognition of the molecular mechanisms of camp action against dna damage-induced apoptosis can be useful to improve the efficacy of dna damaging therapeutic agents. considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-trea...