Purpose: To determine the effect of sevoflurane (SE) on neuronal apoptosis, and mechanism involved.Methods: Sixty healthy male Sprague-Dawley rats were assigned to control, model SE groups. Sham surgery was performed in control group, while middle cerebral artery infarction (MCAO) established group. The expression HO-1 mRNA determined by quantitative real-time polymerase chain reaction (qRT-PCR...

asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. increasing reports have linked airway infectious diseases to asthma. influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. dive...

objective(s): the aim of this study was to determine the important molecules involved in apoptosis induction by opium in jurkat cell line. materials and methods: jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. results: our results demonstrated that 50.3±0.2 percent of opium treated jurkat ...

in this study organotypic adult spinal cord slices were used to investigate whether caspases could participate in the apoptosis of motor neurons. the thoracic region of spinal cord was sliced using a tissue chopper and cultured in a medium for 6h. morphological and biochemical features of apoptosis were assessed by fluorescent staining and terminal deoxynucleotidyl nick end labeling (tunel) met...

background: uterine leiomyoma is the most common tumor among the female in the reproductive period. the first step to control the tumor is employing medical treatment. currently gnrh agonists are the most common drugs for medical therapy of uterine myoma.  climacteric-like symptoms and osteoporosis and recurrence of the size of tumor after gnrh agonists consumption are among the most common sid...

background: phototherapy is believed to be a safe method for the management of hyperbilirubinemia. however, there are some controversial issues regarding the genotoxic effects of phototherapy on dna. the aim of this study was to investigate morphologically both phototherapy-induced dna double-strand breaks (dsbs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. me...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. there is accumulating evidence that oleuropein (oe) has anti-apoptotic effect. the purpose of this study was to determine the anti-apoptotic effect of oe pretreatment in the neuronal cells of cerebral cortex. methods: rats were randomly divided into four groups each containin...

conclusions besides, there are some novel agents, yet under research, which could affect the future of anesthetic agents' fate regarding their hepatic effects. results however, we have evidence that there is some concern regarding their effects on the liver cells. fortunately not all the anesthetics are blamed and even some could be used safely, based on the available evidence. evidence acquisi...

conclusions it seems that the preventive effects of rutin against damages caused by ida can be attributed to its ability to reduce apoptosis, which may be mediated by underexpression of caspase3 and overexpression of bcl2 genes. also, it could increase the expression of dazl that may be important in spermatogenesis. methods in the current experimental study, balb/c mice were divided into 8 grou...

background: nowadays, oocytes and embryos vitrification has become a routine technique. based on clinical judgment, re-vitrification maybe required. but little is known about re-vitrification impact on genes expression. objective: the impact of re-vitrification on apoptotic and implanting genes, bax, bcl-2 and erbb4, at compaction stage embryos were evaluated in this study. materials and method...