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Introduction: The influence of ascorbic acid on the nicotine-induced conditioned place preference (CPP) and behavioral sensitization was investigated in the present study. Methods: In a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. Different doses of a...

introduction: the influence of ascorbic acid on the nicotine-induced conditioned place preference (cpp) and behavioral sensitization was investigated in the present study. methods: in a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. different doses of ascor...

the effects of thiamine, ascorbic acid ami their combination an workers who are continuously exposal to lead has been investigated. in this study 60 persons in a battery industry was selected and divided into four equal groups. group i received placebo, group ii thiamine (300 mg), group iii ascorbic acid (250 mg) anil group iv thiamine (300 mg) plus ascorbic acid (250 mg) three times a day (ora...

after maxillary expansion, a long period of retention is necessary to prevent early relapse. therefore, it is beneficial to accelerate bone formation in the expanding midpalatal suture to reduce relapse. this study was designed to evaluate the effect of dietary vitamin c on osteogenesis of rat midpalatal suture during expansion.fifty-four male wistar rats were randomly divided into three groups...

In this study, a new reaction system for quantitative determination of ascorbic acid was introduced. The developed method is based on inhibitory effect of ascorbic acid on the Orange G-bromate system. The change in absorbance was followed spectrophotometrically at 478 nm. The dependence of sensitivity on the reaction variables including reagents concentration, temperature and time was investiga...

Background & Aims: Stroke is the third leading cause of death. Oxidative stress has a principal role in the complications of stroke. Due to this fact and the antioxidant effects of ascorbic acid, this study was designed to evaluate the effect of ascorbic acid on reduction of stroke complications in a permanent model of middle cerebral artery (MCA) occlusion in male rats. Methods: In this experi...

Ascorbic acid is one of the important water soluble vitamins. It is essential for collagen, carnitine and neurotransmitters biosynthesis. Most plants and animals synthesize ascorbic acid for their own requirement. However, apes and humans can not synthesize ascorbic acid due to lack of an enzyme gulonolactone oxidase. Hence, ascorbic acid has to be supplemented mainly through fruits, vegetables...

osteoporosis is a silent epidemy of today's world, and is also a prevalent problem of health in iran. the role of nutrients such as ascorbic acid, a key antioxidant vitamin, in this disease has recently attracted researchers' attention. in this study, we studied the relation between plasma ascorbic acid concentration and bone mineral density (bmd) in women referring to jami clinic, te...