Introduction and Aim: Concanavalin the lectin from Canavalia spp. share high structural similarity among same taxon exhibit wide range of biological functions. The antiproliferative activity lectins ConA (C. ensiformis), ConC cathartica), ConG gladiata) ConM rosea) were studied in human colon carcinoma. 
 Materials Methods: Human carcinoma HT-29 cells normal kidney HEK293T examined. cytoto...

Abstract Autoimmune hepatitis (AIH) is a serious health problem characterized by cellular infiltration and progressive destruction of the hepatic parenchyma resulting in cirrhosis, liver failure death. In current study, we assessed ameliorative role Δ 8-THC limiting disease severity its regulatory on gut microbiota thereby altering differentiation T cell subsets murine model Concanavalin A-indu...

The early phase of the ConA-induced inflammatory ascites was studied, with special reference to histamine. Concanavalin A (ConA), a cell-surface binding lectin was injected i.p. (25 mg/kg bw) to mice. After 1 h the animals were killed, the ascitic fluid collected and measured. Other agents were injected s.c., 10 min before the ConA-challenge. Exogenous histamine markedly inhibited the ConA-indu...

Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by D-mannose. The kinetics of virus growth was carried out by plaque assay. Electron microscopy and polyacrylamide gel electrophoresis were used f...

Seeds of sword bean (Canavalia gladiata), a leguminous plant, is rich in proteins and cannot be eaten raw because the seed contains toxins, such as concanavalin A (ConA) canatoxin. Therefore, seeds are soaked, boiled, rinsed, pounded before using them protein ingredient. Also, have been utilized natural medicine. Recently, it was reported that consuming tea alleviates allergic rhinitis symptoms...

Incubation of African trypanosomes with the lectin concanavalin A (conA) leads to alteration in cellular DNA content, DNA degradation, and surface membrane blebbing. Here, we report the generation and characterization of a conA-refractory Trypanosoma brucei line. These insect stage parasites were resistant to conA killing, with a mediun lethal dose at least 50-fold greater than the parental lin...

Chlamydomonas flagella are shown to possess two zones of concanavalin A (ConA) binding carbohydrate. The first zone, distinguished by a requirement for a prolonged labelling period for visualization of fluorescein isothiocyanate (FITC)-ConA fluorescence, is localized in the flagellar coat. The second zone is characterized by a rapid FITC- and [125I]ConA labelling subsequent to disruption of the...

Spore-cell differentiation in monolayers in vitro of two sporagenous mutants of Dictyostelium discoideum, HM18 and HM15, is markedly inhibited by relatively low concentrations of the exogenous lectins, Concanavalin A (ConA) and wheat germ agglutinin (WGA) and by somewhat higher concentrations of the endogenous lectin, discoidin. The selective inhibition of spore cell formation by ConA occurs to...

Concanavalin A stimulation of T-cell cytotoxicity has been shown to be absolutely dependent on helper T-cell collaboration. Thymocytes stimulated with ConA do not differentiate to yield cytotoxic effector cells. However, thymocytes cocultured with irradiated spleen cells as helpers and ConA yield high levels of cytotoxicity. The helper cell bears theta antigens on its surface, is not an adheren...

The ability of the jack bean lectin concanavalin A (ConA) to bind seven membered ring (septanose) monosaccharides has been investigated by isothermal titration calorimetry (ITC) and saturation transfer difference (STD) NMR spectroscopy.