objective: dendrimers are three-dimensional nanostructures that have numerous applications in medicine, including drug delivery and imaging. although anionic dendrimer polyethylene glycol–citrate has a high potential to increase solubility of water-insoluble drugs and drug delivery, its multi-step synthesis procedure is time consuming. in addition, toxic substances such as dichloromethane are u...

Liquid Crystals Laboratory, Institute of Science and Technology, Lithuanian University of Educational Sciences, Lithuania Today sensitivity of the MRI is not enough compared to the nuclear methods, such as positron emission tomography and single photon emission computed tomography. Challenging its extension to the nanometre scale could provide a powerful new tool for the nanosciences and nanome...

This study is focused on thermoresponsive glycogen-graft-poly(2-alkyl-2-oxazolines), a new group of nanostructured hybrid dendrimeric stimuli-responsive polymers connecting the body’s own biodegradable polysaccharidic dendrimer glycogen with the widely tuneable thermoresponsive behavior of polypeptide-analogic poly(2-alkyl-2-oxazolines), which are known to be biocompatible. Glycogengraft-poly(2...

Nanoscale assembly is an area of research that has vast implications for molecular design, sensing, nanofabrication, supramolecular chemistry, catalysis, and environmental remediation. Here we show that poly(amidoamine) (PAMAM) dendrimers of both generations 1 (G1) and 4 (G4) can host 1 fullerenol per 2 dendrimer primary amines as evidenced by isothermal titration calorimetry, dynamic light sca...

Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an enhanced, dendritic effect with an exponential increase in cell internalization...

The small-angle neutron scattering (SANS) technique has been used to investigate the structure of dendrimers based on polyhedral oligomeric silsesquioxane (POSS) in solution. Three generations and two distinct terminal groups (either vinyl or polyethylene glycol (PEG) terminal groups) as well as four concentrations for each dendrimer have been measured in deuterated tetrahydrofuran. Two main sc...

A simple synthesis of polymer core-dendrimer shell nanoparticles (NPs) in the 15-20-nm-diameter range is presented. Amine-terminated polypropyleneimine (PPI) dendrimers DAB-dendri-(NH(2))(4) and DAB-dendri-(NH(2))(16) (DAB4 and DAB16) are covalently attached to the surface of primary polystyrene-based NPs bearing reactive chlorobenzyl groups produced by microemulsion polymerization in the prese...

Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated (corresponding to neutral pH) poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single stranded DNAs (ssDNAs). The four ssDNA strands that are attached via alkythiolate [-S (CH2)6-] linker molecule to the fr...