We review the synthesis of dendrimer-containing layer-by-layer (LbL) assemblies and their applications, including biosensing, controlled drug release, and bio-imaging. Dendrimers can be built into LbL films and microcapsules by alternating deposition of dendrimers and counter polymers on the surface of flat substrates and colloidal microparticles through electrostatic bonding, hydrogen bonding,...

The developed theory of the orientational mobility of individual segments of a perfectly branched dendrimer is used to calculate the relaxation spectrum of a dendrimer. Frequency dependences of NMR relaxation 1/T(1) and of the nuclear Overhauser effect have been theoretically calculated from the Brownian dynamics simulation data. The dendrimer segmental orientational mobility is governed by thr...

A target-specific MRI contrast agent for tumor cells expressing high affinity folate receptor was synthesized using generation five (G5) ofpolyamidoamine (PAMAM) dendrimer. Surface modified dendrimer was functionalized for targeting with folic acid (FA) and the remaining terminal primary amines of the dendrimer were conjugated with the bifunctional NCS-DOTA chelator that forms stable complexes ...

The samples of fir'e hybrid dendrimer (lactopolypropylene imine) generations were studied by the methods of molecular hydrod-vnamics, including the sedimentation velocity. translationa] diffusion, and intrinsic viscosity measurement s in 0.l65Vo aqueous NaCl solutions. The molecular masses (1.9 < M sDx 10-3 < 46.5) and the corresponding hydrodynamic dimensions of the dendrimer molecules were de...

We theoretically study the trapping time distribution and the efficiency of the excitation energy transport in dendritic systems. Trapping of excitations, created at the periphery of the dendrimer, on a trap located at its core, is used as a probe of the efficiency of the energy transport across the dendrimer. The transport process is treated as incoherent hopping of excitations between nearest...

In order to transport therapeutic agents across blood brain barrier (BBB) for sustained time in response to biological need, we designed and synthesized novel dendritic nanoparticles with thermoresponsive and biodegradable properties as drug delivery systems. The nano-sized dendrimer was prepared by coupling reaction of poly(L-lysine) (PLL) dendron and poly(Nisopropylacrylamide) (PNIPAAM) graft...

We reported an innovative, targeted chemoimmuno drug-delivery system. Although chemoimmunotherapy, as an alternative to or in combination with conventional therapeutic systems, has been in the forefront of recent oncological research, as presently configured, such systems face several major obstacles for efficient clinical application. Here, we establish a novel nano-platform for effective chem...

Dendrimer-like silica particles with a center-radial dendritic framework and a synergistic hierarchical porosity have attracted much attention due to their unique open three-dimensional superstructures with high accessibility to the internal surface areas; however, the delicate regulation of the hierarchical porosity has been difficult to achieve up to now. Herein, a series of dendrimer-like am...

The biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with acrylic acid and ethylenediamine as repeating units was synthesized by diver...

Since Iijima’s report on carbon nanotubes (CNTs), they have been widely investigated due to their unique properties. In spite of many advantages, the practical applications of CNTs have been limited by their poor dispersibility in solvents, polymers, ceramics and metallic matrices. To overcome this limitation, many chemical and physical approaches to functionalized CNTs have been developed duri...