Major depressive disorder (MDD) is a debilitating illness that affects twice as many women than men postpuberty. This female bias is thought to be caused by greater heritability of MDD in women and increased vulnerability induced by female sex hormones. We tested this hypothesis by removing the ovaries from prepubertal Wistar Kyoto (WKY) more immobile (WMI) females, a genetic animal model of de...

Depression is a serious mental disorder that affects a person's mood, thoughts, behavior, physical health, and life in general. Despite our continuous efforts to understand the disease, the etiology of depressive behavior remains perplexing. Recently, aberrant early life or postnatal neurogenesis has been linked to adult depressive behavior; however, genetic evidence for this is still lacking. ...

Major depression has a high prevalence and a high mortality. In order to understand the molecular changes underlying major depression animal models are needed. The different animal models of depression simulate the etiology and replicates symptoms, course and treatment of human depression properly. In this study, we investigated stress-induced depressogenic induction among the rats using Shuttl...

Decreased circulating melatonin is implicated in depression. We recently found that Zucker diabetic fatty rats (ZDF, fa/fa) develop depression-like behaviors and that transcutaneous auricular vagus nerve stimulation (taVNS) is antidepressive in ZDF rats. Here we studied whether the ZDF rats could be used as a depression rodent model and whether the antidepressive effect of taVNS is mediated thr...

Few studies have assessed the effects of tannery effluents intake in mammalian animal models, despite the discharge of tannery effluents into water bodies without treatment are environmental and public health problems in many countries. This study therefore aimed to evaluate the effects of the mice parental generation exposure to tannery effluent on the anxiety and depression behaviors in its o...

This study was designed to examine the effects of maternal rearing attitudes and depression on children’s compulsive-like behavior, mediated by children’s emotional traits. A questionnaire was completed by 116 mothers of 3 6-year-old children. There were no significant correlations between maternal factors and compulsive-like behavior in children. However, structural equation modeling using chi...

Dietary fat plays an important role in higher brain functions. We aimed to assess the short and long term intake of three different types of dietary fat (soybean oil, lard, and fish oil) on anxiety-like and depression-like behavior in mice. For the short term intake assessment, a behavioral test battery for anxiety and depression was carried out for a 3-day feeding period. For the long term int...

Depression and/or anxiety are major comorbidities of epilepsy. However, the contribution of absence epileptic discharges in psychiatric syndromes is inconclusive. This study aimed to clarify the influence of absence seizure in anxiety- and depression-like behaviors using normal Wistar rats and Long-Evans rats with spontaneous spike-wave discharges (SWDs). Anxiety-like behaviors were evaluated b...