BACKGROUND Depression and anxiety are common and independent outcome predictors in patients with chronic heart failure (CHF). However, it is unclear whether CHF causes depression. Thus, we investigated whether mice develop anxiety- and depression-like behavior after induction of ischemic CHF by myocardial infarction (MI). METHODS AND RESULTS In order to assess depression-like behavior, anhedo...

Calcitonin gene-related peptide (CGRP) is a neuropeptide that has potent vasodilator properties and is involved in various behavioral disorders. The relationship between CGRP and depression-like behavior is unclear. In this study, we used chronically stressed mice to investigate whether CGRP is involved in depression-like behavior. Each mouse was exposed to restraint and water immersion stress ...

In this set of experiments, we examined a number of variables that are crucial to determining the effects of fibroblast growth factor-9 (FGF9) on affective behavior. Animals were injected on post-natal day two (PND2) to determine whether a single early-life subcutaneous (s.c.) injection had long-lasting effects on adult behavior as was observed with FGF2. We observed no significant changes in a...

salvia verticillata is one of the salvia species which possesses remarkable antioxidant activity. in the present study, we investigated the possible effects of hydro-alcoholic extract from salvia verticillata plant (sve) in various models of anxiety, depression and seizure in mice. mice were randomly divided into control (saline), sve-treated and standard treatment groups. the sve-treated group...