conclusions our findings introduced a novel therapeutic effect of diet therapy on circulating mirnas in obese patients with t2dm. mir-33b is an important therapeutic target in the treatment and prevention of t2dm and its complications. results the circulating levels of mir-29a and mir-33b in the diabetic women were higher (0.40-fold) and lower (1.43-fold), respectively, than normal levels. diet...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

objective(s):the neuroprotective effect offruit aqueous extract of ziziphus jujuba lam on glucose-induced neurotoxicity in pc12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. materials and methods: cell viability was determined by the mtt assay. cellular reactive oxygen species (ros) generation was measured by dcfh-da analysis. cleaved caspase-3, a biochemical p...

introduction in neonates and small infants, early diagnosis of central diabetes insipidus (cdi) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. case presentetion we described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopre...

background: in view of the importance of teachers and faculties in changing the perspective of population on this issue, and also the increasing rate of prostate cancer screening, the present study was carried out to evaluate the knowledge base, attitude and performance of teachers and faculty members in relation to prostate cancer screening test. objective: in this study,we evaluated the teach...

introduction: there is evidence that diabetes affects seizure susceptibility. ginger (zingiber officinale roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. the aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (ptz) in diabetic mice after induction of diabetes with streptozocin and to examine the possible role...

background: self care of diabetes is essential for control of disease and improvement of quality of patients' life. the aim of this study was to assess factors influencing self-care practice of patients in urban area of urmia, northwest of iran. methods: in this cross-sectional study, 400 diabetic patients were randomly selected from eight healthcare centers in urmia city in 2010. data collecti...

background: low compliance with drugs regimens in diabetic patients is one of the greatest challenges in the treatment of diabetes. the aim of this study was to evaluate compliance with medical orders in diabetic patients referred to the endocrinology clinic of afzalipour hospital, kerman, iran. methods: in this cross sectional study 345 of the 3000 patients, who referred to the endocrinology c...

background: diabetes mellitus is one of the most important causes of morbidity and mortality all over the world. chronic high blood glucose is the root cause of developing future micro and macro vascular complications. in current study, we analyzed poorly controlled patients’ information by clustering method in order to find more homogenous sub-groups of patients for planning for further interv...