نتایج جستجو برای: dt
تعداد نتایج: 15686 فیلتر نتایج به سال:
The large-scale images and videos are one kind of the main source of big data. Dynamic texture (DT) is essential for understanding the video sequences with spatio-temporal similarities. This paper presents a powerful tool called dynamic fractal analysis to DT description and classification, which integrates rich description of DT with strong robustness to environmental changes. The proposed dyn...
Diphtheria toxin (DT) is a soluble protein that translocates across hydrophobic lipid bilayers in response to low pH. The translocation activity of DT has been localized to the 40-kDa toxin B chain and can be expressed independently of the C-terminal receptor binding site. Buried hydrophobic domains in DT are thought to participate in the membrane translocation process. We have identified a mut...
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II
The mitochondrial respiratory chain, including mitochondrial complex II, has emerged as a potential target for cancer therapy. In the present study, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), DT-010, was synthesized. Our results showed that DT-010 is more potent than its parental compounds separately or in combination, in inhibiting the proliferation of MCF-7 and MDA-MB...
Tissue hypoxia contributes to solid tumor pathogenesis by activating a series of adaptive programs. We previously showed that hypoxia promotes the preferential expansion and maintenance of CD133 positive human glioma stem cells (GSC) in a hypoxia inducible factor 1 alpha (HIF-1α)-dependent mechanism. Here, we examined the activity of digitoxin (DT), a cardiac glycoside and a putative inhibitor ...
D-dopachrome tautomerase (D-DT/MIF-2) is a member of the macrophage migration inhibitory factor (MIF) cytokine superfamily, and a close structural homolog of MIF. MIF and D-DT have been reported to be involved in obesity, but there is little known about the regulation of D-DT in adipose tissue inflammation and wound healing. Subcutaneous adipose tissue was collected from 54 healthy donors and 2...
Although equine diphtheria antitoxin may be an effective therapy for human diphtheria, its use often induces serum sickness. We describe here a strategy for developing an alternative treatment based on the human diphtheria toxin (DT) receptor/heparin-binding epidermal growth factor-like growth factor (HB-EGF) precursor. Recombinant mature human HB-EGF acts as a soluble receptor analog, binding ...
The maximal rate of fall in right ventricular pressure (negative dp/dt) was evaluated in 34 patients. Eight had normal pulmonary arterial pressure. Seventeen had pulmonary arterial hypertension, and nine had pulmonary arterial hypertension with right ventricular failure. The right ventricular maximal negative dp/dt in patients with normal pulmonary arterial pressure was 170 +/- 20 mm Hg/sec. In...
(1) Compute the Laplace transform of f (t) = t e 3t from its definition. Solution. The definition of the Laplace transform gives L[f ](s) = lim T →∞ T 0 e −st t e 3t dt = lim T →∞ T 0 t e (3−s)t dt. This limit diverges to +∞ for s ≤ 3 because in that case T 0 t e (3−s)t dt ≥ T 0 t dt = T 2 2 , which clearly diverges to +∞ as T → ∞. For s > 3 an integration by parts shows that T 0 t e (3−s)t dt ...
In this paper, oscillatory and asymptotic property of solutions of a class of nonlinear neutral delay differential equations of the form (E) d dt (r(t) d dt (y(t) + p(t)y(t− τ))) + f1(t)G1(y(t− σ1))− f2(t)G2(y(t− σ2)) = g(t) and d dt (r(t) d dt (y(t) + p(t)y(t− τ))) + f1(t)G1(y(t− σ1))− f2(t)G2(y(t− σ2)) = 0 are studied under the assumptions ∞ ∫ 0 dt r(t) <∞ and ∞ ∫
DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear. Hence, this study was undertaken to elucidate the protective effect of DT-13 on TNF-α-i...
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