Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhanced cognitive functions in ovariectomized animals. Here, we provide evidence tha...

The seed cycling/seed rotation diet is a new trend that claims to be effective for female menstrual dysfunctions such as irregular menstruation, cramps, infertility, menopausal symptoms (hot flashes, fatigue, etc.), and PCOS. higher prevalence of hormonal imbalance in women contributing factor all these dysfunctions. major hormones control menstruation females include progesterone, estrogen, lu...

Abstract Purpose Previous studies have reported a sympatholytic action of estrogen on the vasculature in response to increased sympathetic outflow, an effect most notable during exercise, providing for necessary increases blood flow working muscle. In contrast, elevated concentrations progesterone can inhibit this estrogen, impairing flow. We hypothesize that peak concentration proliferative po...

Abstract Estrogen, the major female sex hormone has been linked with immune response disparity between males and females. However, exact mechanism by which estrogen impacts our ability to fight viral infection development of immunologic memory remains unknown. CD8 T cells represent primary protective against viruses cancer. Here we aim understand how cell mediated antiviral is regulated estroge...

BACKGROUND In the Women's Health Initiative Randomized Controlled Trial (WHI RCT), estrogen-only treatment compared with combined estrogen-progestin treatment resulted in less coronary artery disease, no increase in breast cancer and no reduction in colorectal cancer. Since we previously reasonably replicated the combined estrogen-progestin WHI RCT using the UK General Practice Research Databas...

This study aimed to investigate the concentrations effect of some Electrolytes (Sodium, Potassium, and Magnesium) Lipids compounds (Cholesterol, Triglycerides, high density lipoprotein, low very lipoprotein), sex hormones (estrogen testosterone) on atherosclerosis disease. The included a comparison between 60 patients from both male female with heart disease, 40 healthy gender. age ranged (30 -...

Postmenopausal osteoporosis is characterized by declining estrogen levels, and estrogen replacement therapy has been proven beneficial for preventing bone loss in affected women. While the physiological functions of estrogen in bone, primarily the inhibition of bone resorption, have been studied extensively, the effects of pharmacological estrogen administration are still poorly characterized. ...

Estrogen receptors (ERs) are nuclear transcription factors that regulate gene expression in response to estrogen and estrogen-like compounds. Identification of estrogen-regulated genes in target cells is an essential step toward understanding the molecular mechanisms of estrogen action. Using cDNA microarray examinations, 19 genes were identified as induced by 17 beta-estradiol in MCF-7 cells, ...

Activin is a member of the transforming growth factor beta superfamily that regulates mammary cell function during development, lactation, and in cancer. Activin slows the growth of breast cancer cells by inducing G(0)/G(1) cell cycle arrest. Estrogen is a steroid hormone that stimulates the proliferation of mammary epithelial cells in development and oncogenesis. The crosstalk between estrogen...

The value of estrogen replacement in postmenopausal women is well documented. Estrogen prevents or modifies the disease course of osteoporosis, I coronary artery disease,2-4 and atrophic vaginitis, and it often is used to treat urinary incontinence. The role of estrogen replacement in prevention of strokes is more controversial; some studies suggest a positive roleS and others suggest no role.6...