We tested the hypothesis that intracarotid estrogen infusion increases cerebral blood flow (CBF) in a concentration-dependent manner and direct application of estrogen on pial arterioles yields estrogen receptor-mediated vasodilation. Rabbits of both genders were infused with estrogen via a branch of the carotid artery. Estrogen doses of 20 or 0.05 microg. ml(-1). min(-1) were used to achieve s...

Breast cancer remains one of the most frequent malignancies in women and primary cause cancer-related death all over world. Hormones tumor biomarkers have been implicated as possible causes prognostic breast cancer. The present study investigated use serum hormonal levels biomarkers; Carcinoembrvonic antigen (CEA), (CA 15-3) for diagnosis Cancer, generation different subtypes using Estrogen rec...

CONTEXT Estrogen and its metabolites play a critical role in the pathophysiology of the endometrium. The bioavailability of estrogen and estrogen metabolites in endometrial tissues depends on the expression of enzymes involved in estrogen biosynthesis and metabolism. Substantial evidence indicates that estrogen-dependent endometrial disorders are also associated with proinflammatory milieu. How...

Selective estrogen receptor modulators, like tamoxifen and related compounds, have mixed estrogen agonistic/antagonistic effects. Tamoxifen may confer significant cardiovascular benefits without the estrogen-associated risks of endometrial and breast cancer. Droloxifene, a structural analogue of tamoxifen, has estrogen agonistic effects on bone and antagonistic effects on endometrial and breast...

The gonadal steroid estrogen exerts an important modulatory influence on the activity of multiple neuronal networks. In addition to classical genomic mechanisms of action, estrogen also exerts poorly understood rapid, nongenomic effects on neurons. To examine whether estrogen may exert rapid actions on intracellular signaling within gonadotropin-releasing hormone (GnRH) neurons in vivo,we exami...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

the hippocampal system plays an important role in memory function. neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. many biological effects of estrogens in the brain via estrogenic receptors (ers) are investigated. the current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

introduction: breast cancer is the most common cancer in women worldwide and her-2 is one importantly prognostic factor in this cancer. tumor markers use as a criterion for predicting recurrence, but in breast cancer physical examination and mammography are important factors that are recommended for following up the recurrence. the aim of this study was to assess the correlation between breast ...

conclusions erα expression in liver was inversely correlated with liver fibrosis among patients infected with chronic hcv genotype 1b. patients and methods all the consecutive patients who received the same standard treatment protocol for hcv genotype 1b were subdivided into two subgroups according to their fibrosis scores as fibrotic stages < 2 in mild fibrosis group and fibrotic stages ≥ 2 in...