Objective(s): This study aimed to investigate the effect of aerobic training on serum levels of Klotho, cardiac tissue levels of H2O2 and phosphorylation of ERK1/2 and P38 as well as left ventricular internal diameter (LVID), the left ventricle wall thickness (LVWT) and fibrosis in middle-aged rats. Materials and Methods: Forty wistar rats, including young rats (n=10, 4 month-old) and middle-ag...

ABSTRAK
 Sekitar 80-90% pasien cystic fibrosis akan mengalami pancreatic insuffiency. Keadaan ini menyebabkan terjadinya malabsorpsi lemak dan protein berpengaruh pada status nutrisi dari pasien. Terapi insufficiency adalah dengan pemberian enzyme replacement therapy (PERT) untuk meningkatkan absorpsi juga fibrosis. Tujuan kajian sistematis mengetahui efikasi keamanan terapi PERT yang sehi...

On March 11, 2020, the World Health Organization (WHO) released a statement characterizing COVID-19 as pandemic that has, of October caused almost 36 million confirmed global cases and over 1 deaths. One long-term complications suggested by researchers is fibrosis. It has been hypothesized combination ongoing pulmonary injury inability to promptly repair damage results in interstitial matrix wi...

This paper presents four cases of abnormal soft tissue activity in the bone scan of patients with different lesions (lung inflammatory pseudotumor, pulmonary fibrosis, pulmonary metastatic osteosarcoma and metastatic hepatic carcinoma of colon).

: This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and evaluate the regulatory effect of traditional Chinese medicine (TCM) on flora, providing new insights into treatment. Destruction microbiome can lead development, accelerating microbiome’s disruption. TCM effectively regulate helping prevent treat fibrosis. review discusses mechanisms behind changes in t...

Improving standards of care and new therapeutics means individuals with cystic fibrosis are living longer, but this brings an increased risk non-communicable diseases, especially cardiovascular disease (CVD). To improve both longevity quality life, it is important to consider CVD prevention in those fibrosis.

BACKGROUND Bone marrow fibrosis in patients with myelodysplastic syndrome is associated with a poor outcome, but whether the outcome after allogeneic stem cell transplantation is related to the degree of bone marrow fibrosis is unknown. DESIGN AND METHODS Patients with myelodysplastic syndrome and known bone marrow histology (n=721) who underwent hematopoietic stem cell transplantation were c...

Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...

Combined therapy with clarithromycin (CLTR) and N–acetyl cysteine (NAC) may be useful in diseases with impaired oxidant-antioxidant balance, fibroblast proliferation, and collagen deposition such as pulmonary fibrosis. Activated inflammatory cells which accumulate in the lower airways may release increased amounts of reactive oxygen species (ROS) when accompanied with a deficiency in glut...