نتایج جستجو برای: floor plate

تعداد نتایج: 105077  

Journal: :Mechanisms of Development 2009
C. Albert Noyes Xiaofen Want Ekaterina P. Hatch Suzanne L. Mansour

The axial tissues of the vertebrate embryo is a term that refers collectively to the floor plate (a cell population that lies at the ventral floor of the neural tube) and the notochord (which is a mesodermal rod of cells located immediately ventral to the floor plate). The notochord and floor plate both secrete the morphogen signal Sonic Hedgehog (Shh) that patterns the dorsoventral axis of the...

Journal: :Mechanisms of Development 2009
Siwei Zhang

The axial tissues of the vertebrate embryo is a term that refers collectively to the floor plate (a cell population that lies at the ventral floor of the neural tube) and the notochord (which is a mesodermal rod of cells located immediately ventral to the floor plate). The notochord and floor plate both secrete the morphogen signal Sonic Hedgehog (Shh) that patterns the dorsoventral axis of the...

2012
Margaret D. Cass Samantha J. Butler

During embryonic development, commissural axons, originating in the dorsal spinal cord, send axons ventrally towards the floor plate. The trajectory of these axons is mediated by both repulsive cues secreted from the roof plate, as well as attractive cues secreted from the floor plate. To investigate the guidance activity of the floor plate, we first attempted to examine the role of Sonic Hedge...

Journal: :Current Biology 2002
Iain Patten Marysia Placzek

We performed in vivo experiments in chick embryos that examined whether application of an exogenous source of Shh protein mimics the ability of the notochord to induce ectopic floor plate cells in the neural tube. Shh cannot act alone to induce a floor plate. However, coapplication of Shh and chordin, a BMP antagonist normally coexpressed with Shh in the notochord, results in a marked switch fr...

Journal: :Development 2005
Silvia L López María V Rosato-Siri Paula G Franco Alejandra R Paganelli Andrés E Carrasco

We have previously shown that the early Xenopus organiser contains cells equally potent to give rise to notochord or floor plate, and that Notch signalling triggers a binary decision, favouring the floor plate fate at the expense of the notochord. Now, we present evidence that Delta1 is the ligand that triggers the binary switch, which is executed through the Notch-mediated activation of hairy2...

Journal: :Mechanisms of Development 2012
Kyung-Suk Choi Chanmi Lee Brian D. Harfe

The intervertebral discs, located between adjacent vertebrae, are required for stability of the spine and distributing mechanical load throughout the vertebral column. All cell types located in the middle regions of the discs, called nuclei pulposi, are derived from the embryonic notochord. Recently, it was shown that the hedgehog signaling pathway plays an essential role during formation of nu...

Journal: :Development 2010
Catarina Cruz Vanessa Ribes Eva Kutejova Jordi Cayuso Victoria Lawson Dominic Norris Jonathan Stevens Megan Davey Ken Blight Fiona Bangs Anita Mynett Elizabeth Hirst Rachel Chung Nikolaos Balaskas Steven L Brody Elisa Marti James Briscoe

Sonic hedgehog signalling is essential for the embryonic development of many tissues including the central nervous system, where it controls the pattern of cellular differentiation. A genome-wide screen of neural progenitor cells to evaluate the Shh signalling-regulated transcriptome identified the forkhead transcription factor Foxj1. In both chick and mouse Foxj1 is expressed in the ventral mi...

Journal: :Development 2008
W Todd Farmer Amy L Altick Hikmet Feyza Nural James P Dugan Thomas Kidd Frédéric Charron Grant S Mastick

Longitudinal axons transmit all signals between the brain and spinal cord. Their axon tracts through the brain stem are established by a simple set of pioneer axons with precise trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or geneti...

Journal: :Development 1997
H Sasaki C Hui M Nakafuku H Kondoh

The floor plate plays important roles in ventral pattern formation and axonal guidance within the neural tube of vertebrate embryos. A critical event for floor plate development is the induction of a winged helix transcription factor, Hepatocyte Nuclear Factor-3beta (HNF-3beta). The enhancer for floor plate expression of HNF-3beta is located 3' of the transcription unit and consists of multiple...

Journal: :Mechanisms of Development 1998
Nicholas D.E Greene Dianne Gerrelli Henny W.M Van Straaten Andrew J Copp

Mouse embryos homozygous for the loop-tail (Lp) mutation fail to initiate neural tube closure at E8.5, leading to a severe malformation in which the neural tube remains open from midbrain to tail. During initiation of closure, the normal mouse neural plate bends sharply in the midline, at the site of the future floor plate. In contrast, Lp/Lp embryos exhibit a broad region of flat neural plate ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید