Ameliorative potential of antioxidants –vitamins C and E on blood profile of Clarias gariepinus fed diets contaminated with varied levels of fumonisin B1 (FB1) was evaluated. Fusarium cultured maize containing FB1 were used to formulate diets containing approximately 2.5, 5.0, and 7.5 mg FB1/kg constituting diets 2, 3, and 4, respectively and other nine diets constituting Diets 5 - 13 with the ...

The efficacy of cold atmospheric pressure plasma (CAPP) with ambient air as working gas for the degradation of selected mycotoxins was studied. Deoxynivalenol, zearalenone, enniatins, fumonisin B1, and T2 toxin produced by Fusarium spp., sterigmatocystin produced by Aspergillus spp. and AAL toxin produced by Alternaria alternata were used. The kinetics of the decay of mycotoxins exposed to plas...

This study examines the role of sphingolipids in mediating the apoptosis of PC12W cells induced by the angiotensin II type 2 (AT2) receptor. PC12W cells express abundant AT2 receptor but not angiotensin II type 1 receptor and undergo apoptosis when stimulated by angiotensin II. AT2 receptor-induced ceramide accumulation preceded the onset of caspase 3 activation and DNA fragmentation. AT2 recep...

The cancer potency was estimated for fumonisin B1 using an expedited method. The dose-response data used in the analysis was generated by the National Toxicology Program ([NTP], 2001a; b) and summarized by Gold and colleagues (Gold & Zeiger, 1997; Gold, 2007) in the Carcinogenic Potency Database (CPDB). The expedited method represents the first level of a three-tiered risk assessment procedure ...

Plasma cells (PCs) are terminally differentiated B lymphocytes responsible for the synthesis and secretion of Igs. The differentiation of B cells into PCs involves a remarkable expansion of both lipid and protein components of the endoplasmic reticulum. Despite their importance in many signal transduction pathways, the role of ceramides, and of complex sphingolipids that are derived from cerami...