Gastroparesis is a condition characterized by delayed gastric emptying and the most common known underlying cause is diabetes mellitus. Symptoms include nausea, vomiting, abdominal fullness, and early satiety, which impact to varying degrees on the patient's quality of life. Symptoms and deficits do not necessarily relate to each other, hence despite significant abnormalities in gastric emptyin...

This review will focus on the pacemaker mechanisrns underlying gastrointestinal autonomic rhythmicity in an attempt to elucidate the differences and similarities between the pacemaker mechanisrns in the heart and gut. Interstitial cells of Cajal (ICC) form networks that are widely distributed within the submucosal (ICC-SM) , intra-muscular (ICCIM, ICC-DMP) and inter-muscular layers (ICC-MY) of ...

This review will focus on the pacemaker mechanisms underlying gastrointestinal autonomic rhythmicity in an attempt to elucidate the differences and similarities between the pacemaker mechanisms in the heart and gut. Interstitial cells of Cajal (ICC) form networks that are widely distributed within the submucosal (ICC-SM), intra-muscular (ICC-IM, ICC-DMP) and inter-muscular layers (ICC-MY) of th...

The proposed functions of the interstitial cells of Cajal (ICC) are to 1) pace the slow waves and regulate their propagation, 2) mediate enteric neuronal signals to smooth muscle cells, and 3) act as mechanosensors. In addition, impairments of ICC have been implicated in diverse motility disorders. This review critically examines the available evidence for these roles and offers alternate expla...

natural substances extracted from plants have recently been considered as potential sunscreen resources because of their ultraviolet ray absorption in the uva region and their antioxidant activity. in the present study, the uv protective effects of ethyl acetate extracts of some common medicinal plants, which have flavonoids and other phenolics as the most important components, were evaluated u...

BACKGROUND Gastroparesis is defined as an inhibition of the gastric motility associated with delayed gastric emptying, which is mainly presented with acute dyspepsia. Gastroptosis is the downward displacement of the stomach. CASE REPORT We report a rare case of secondary gastroparesis due to gastroptosis in an 11-year-old female child. The patient complained for bulking mass in the left lower...

Aetna considers a wireless capsule for measuring gastric emptying parameters (SmartPill GI Monitoring System) experimental and investigational for the evaluation of gastric disorders (e.g., gastroparesis), intestinal motility disorders (e.g., chronic constipation), and all other indications because of inadequate published evidence of its diagnostic performance and clinical utility over conventi...

CONTEXT Gastroparesis is defined by delayed gastric emptying without mechanical obstruction of the gastroduodenal junction, which has been increasingly investigated. Nevertheless, knowledge on the relationships between etiology, symptoms and degree of delayed gastric emptying is limited. OBJECTIVES The demographic, clinical and etiological features of Brazilian patients with gastroparesis wer...

The stomach is the segment of the gastrointestinal tract in which the main secretory functions and digestion in the alimentary canal begins. However, it’s most critical and important function in digestive physiology is gastric motility (GM). Normal GM is controlled by diverse extrinsic and intrinsic stimuli. The main extrinsic regulation comes from the vagal nerve. Although the majority of vaga...