poorly controlled type 2 diabetes mellitus was admitted to hospital following 3 weeks of nausea and nocturnal vomiting, and weight loss of 4 kg. On physical examination, she had a soft abdomen and a palpable gallbladder. Abdominal radiography using water-soluble oral contrast medium (Figure 1) showed pooling in the pelvic region. Computed tomography performed immediately after radiography showe...

BACKGROUND Diabetes mellitus is associated with many kinds of complications. Recent studies have shown that oxidative stress and inflammatory reactions have critical roles in the pathogenesis of diabetic gastroparesis. Curcumin is known to have antioxidant and anti-inflammatory properties. In the present study, we investigated the effect of curcumin on diabetic gastric motility in a Sprague Daw...

Abstract Gastroparesis is a serious medical condition characterized by delayed gastric emptying. An innate immune dysregulation and injury to the interstitial cells of Cajal other components enteric nervous system likely central pathogenesis gastroparesis. We have done GWAS comparing idiopathic diabetic cases with controls as well contrasting versus cases. report novel genetic association SLC15...

Diabetic gastroparesis is associated with increased oxidative stress attributable to loss of upregulation of heme oxygenase-1 (HO1), with resultant damage to interstitial cells of Cajal and delayed gastric emptying. These changes can be reversed by induction of HO1. HO1 catalyzes the breakdown of heme into iron, biliverdin and, carbon monoxide (CO). The aim of this study was to determine whethe...

Delayed gastric emptying can be due to muscular, neural, or humoral abnormalities. In the absence of an identified cause, gastroparesis is labelled as idiopathic. We present the case of a patient with severe idiopathic gastroparesis. Pharmacological approaches failed, as well as reduction in gastric emptying resistance with pyloric injection of botulinum toxin and pyloroplasty. Therefore, subto...

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Gastroparesis is a chronic motility disorder that delays, in the absence of mechanical o...

Canda et al. [1] focused on the changes of interstitial cells of Cajal (ICCs) and neuronal tissue related to diabetes. The results of the current study showed that the number of ICCs in the lamina propria and detrusor muscle is decreased in diabetic patients. This may be an underlying pathomechanism of lower urinary tract symptoms in patients with diabetes. Long lasting diabetes results in diff...

astroparesis is a clinical condition associated with Gdelayed gastric emptying in the absence of mechanical obstruction. Patients present with nausea, vomiting, bloating, and early satiety. The underlying cause may be related to diabetes but also can be caused by upper gastrointestinal surgery, neurologic disease, collagen vascular disease, viral infections, and drugs. In approximately 35% of p...

Gastroparesis (GP), defined as delayed gastric emptying in the absence of any mechanical obstruction, is a challenging clinical condition, mainly because of limited treatment options. Studies in animal models of delayed gastric emptying as well as patients with gastroparesis revealed depletion or ultrastructural changes of interstitial cells of Cajal (ICC) in the gastric tissue, recently termed...

Patients with gastroparesis often present a challenge to the treating physician. Postprandial symptoms with nausea and vomiting may not only lead to nutritional and metabolic consequences, but also cause significant disruptions to social activities that often center around food. While the definition of gastroparesis focuses on impaired gastric emptying, treatment options that affect gastric fun...