BACKGROUND The histopathology of the gastric mucosa in patients with gastroparesis, a condition characterized by gastric retention without obstruction, has not been described. AIM To test the hypothesis that reactive gastropathy is more common in patients with gastroparesis than in subjects with normal gastric motility. METHODS We compared the prevalence of reactive gastropathy, Helicobacte...

BACKGROUND Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms in the HO1 gene (HMOX1, NCBI Gene ID:3162) are associated with worse outcomes in other diseases. AIM ...

Eucalyptus tereticornis is a plant used in traditional medicine to control diabetes, but this effect has not been proved scientifically. Here, we demonstrated through in vitro assays that E. tereticornis extracts increase glucose uptake and inhibit their production in insulin-resistant C2C12 and HepG2 cells, respectively. Furthermore, in a nutritional model using diabetic mice, the administrati...

Interstitial cells of Cajal (ICC) is a peculiar cell network composed of cells having processes described by the eminent Spanish neuroanatomist of the 19th century, S. Ramon y Cajal. ICC became a fascinating subject to many investigators and it is estimated that there are over 100 publications yearly on the subject related to ICC, in the last three years. Now it is widely accepted that ICC are ...

Herbal therapies are commonly used to treat or manage various diseases including diabetes mellitus. Pimpinella tirupatiensis is Indian traditional medicine and the plant has been a popular remedy for various diseases such as antitumor genic, antimicrobial, purgative, analgesic, antiseptic, antipyretic and anti-inflammatory. The current study was intended to evaluate the antidiabetic efficacy of...

Trichobezoars are gastric concretions composed of hair, usually found in long haired girls or young women [1]. Definite correlation exists between bezoars and psychotic illness and disorders affecting gut motility especially gastroparesis diabetecorum [2, 3, 4]. Most bezoars have come to the attention of surgeons when the bezoar passed from the stomach to the small intestine and caused obstruct...

The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. But few studies have explored the pharmacological effect of Prunus persica (L.) Batsch flowers on gastrointestinal motility. In this study, the activities of different extracts from Prunus persica (L.) Batsch flo...