Mesenchymal stromal cells (MSCs) are non-specialized adult stem (ASCs), that reproduce to provide specific cytotypes [...]

Introduction: During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. The first adult stem cells isolated from dental tissues were dental pulp stem cells (DPSCs). When transplanted with hydroxyl apatite/tri calcium phosphate (HA/TCP) powder, they formed a dentin-like structure...

Microfluidics-based technologies are emerging solutions towards cell separation process. They rely on various physical principles, such as dielectrophoretic force, hydrodynamic and acoustic force. In order to take advantage of these approaches for sorting, it is crucial characterize biophysical properties, i.e. size, density, compressibility or contrast factor in the case acoustophoresis. Vario...

Background and Aims: Previous studies have shown that adipose-derived mesenchymal stem/ stromal cells are one of the sources of mesenchymal stem cells (MSCs) with the capacity to differentiate into various mesodermal cell lineages. MSCs with cytokines secretion capability, which contributes to repair damaged tissues have gained wide credence for future cell-based therapeutic applications. In th...

Introduction: Mesenchymal multipotent stromal cells (mesenchymal stem cells-MSCs) are currently the most promising and widely used means of cell therapy. Common sources for obtaining them bone marrow adipose tissue, but now umbilical cord placenta gaining more popularity, since isolated from have a number advantages over other sources. Aim: To study peculiarities human MSCs influence on regener...

In both preclinical and clinical studies, cell transplantation of several cell types is used to promote repair of damaged organs and tissues. Nevertheless, despite the widespread use of such strategies, there remains little understanding of how the efficacy of cell therapy is regulated. We showed previously that augmentation of a unique, metabolically derived stress signal (i.e., O-GlcNAc) impr...

Beneficial effects of intracerebral transplantation of mesenchymal stromal cells (MSC) and their derivatives are believed to be mediated mostly by factors produced by engrafted cells. However, the mesenchymal cell engraftment rate is low, and the majority of grafted cells disappear within a short post-transplantation period. Here, we hypothesize that dying transplanted cells can affect surround...

The Low-Affinity Nerve Growth Factor Receptor (LNGFR), also known as CD271, is a member of the tumor necrosis factor receptor superfamily. The CD271 cell surface marker defines a subset of multipotential mesenchymal stromal cells and may be used to isolate and enrich cells derived from bone marrow aspirate. In this study, we compare the proliferative and differentiation potentials of CD271+ and...