The N-heterocyclic carbene (NHC)-organocatalyzed enantioselective annulation reaction of pyrazolones with α,β-unsaturated aldehydes proceeding via the chiral α,β-unsaturated acyl azolium intermediates under oxidative conditions is presented. The reaction afforded dihydropyranone-fused pyrazoles in moderate to good yields and good er values under operationally simple and base-free conditions.

3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.

caffeic acid phenethyl ester(cape) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. a group of heterocyclic esters of caffeic acid was synthesized using mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol...

In the present research, silica bonded n-propyl-1,3,5-triazine-2,4,6-triamine (SPTT) was synthesized by direct incorporation of chloropropyl groups through co-condensation of tetraethyl orthosilicate (TEOS) and 3-chloropropyl trimethoxysilane (CPTMS) and subsequent grafting the melamine onto the propyl groups via simple nucleophilic substitution reaction. The catalyst has been characterized by ...

Heterocyclic compounds are those cyclic compounds in which one or more of the ring carbons are replaced by another atom. The non-carbon atoms in such rings are referred to as ‘‘heteroatoms.’’ Such bicyclic heterocyclic compounds containing pyrrole ring with benzene ring fused to a,b-position are known as Indoles. Indole has a benzene ring and pyrrole ring sharing one double bond. It is a hetero...

Abstract: Heterocyclic compounds occupy a central position among those molecule that makes life possible. The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4thiadiazole constitutes constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their c...

We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.

The title compound, C(12)H(14)O(4), is an important inter-mediate in the synthesis of biologically active heterocyclic compounds. In the crystal structure, inter-molecular O-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules. There are also C-H⋯π contacts between the benzene ring and the methyl-ene groups.