The recent development of petawatt-class lasers with kilojoule-picosecond pulses, such as OMEGA EP [L. Waxer et al., Opt. Photonics News 16, 30 (2005)], provides a new diagnostic capability to study inertial-confinement-fusion (ICF) and high-energy-density (HED) plasmas. Specifically, petawatt OMEGA EP pulses have been used to backlight OMEGA implosions with energetic proton beams generated thr...

Abstract Background Hypohidrotic Ectodermal Dysplasia (HED) is a genetic disorder which affects structures of ectodermal origin. X-linked hypohidrotic dysplasia (XLHED) the most common form disease. XLHED characterized by hypotrichosis, hypohydrosis and hypodontia. The cardinal features classic HED become obvious during childhood. Identification hemizygous EDA pathogenic variant in an affected ...

High resolution two dimensional electrophoresis (2DE) remains the core technology for resolving complex protein mixtures, prior to mass spectrometry characterization. Due to the complexity of brain tissue, optimising protein separation techniques is fundamental to unravel the function of brain proteins and their role in disease. So, brain tissue is a very good model to improve resolution due to...

The 11C-labeled tracer meta-hydroxyephedrine (11C-HED) is a noradrenaline analog that was developed to visualize the sympathetic nervous system with PET. Initial clinical studies show a rapid uptake of 11C-HED in localized tumors of this system. Whole-body imaging with 11C-HED PET is now possible as PET/CT scanners allow a rather short examination time. The aim of this study was to evaluate the...

Positron emission tomography in combination with the newly introduced catecholamine analogue [11C]hydroxyephedrine ([11C]HED) enables the noninvasive delineation of sympathetic nerve terminals of the heart. To address the ongoing controversy over possible reinnervation of the human transplant, 5 healthy control subjects and 11 patients were studied after cardiac transplant by this imaging appro...

Patients with hypohidrotic ectodermal dysplasia (HED) and Tabby (Ta) mice lack sweat glands and there is compelling evidence that these phenotypes are caused by mutations in the same highly conserved but unidentified X-linked gene. Previous studies showed that exogenous epidermal growth factor (EGF) reversed the Ta phenotype but the EGF status in HED patients has not been studied at all. Studie...

High-energy-density (HED) hydrodynamics studies such as those relevant to inertial confinement fusion and astrophysics require highly disparate densities, temperatures, viscosities, other diffusion parameters over relatively short spatial scales. This presents a challenge for high-order accurate methods effectively resolve the at these scales, particularly in presence of diffusion. A significan...

AIM To assess the association between heavy episodic drinking (HED) and deliberate self-harm (DSH) in young people in Norway. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS We analysed data on past-year HED and DSH from the second (1994) and third (1999) waves of the Young in Norway Longitudinal Study (cumulative response rate: 68.1%, n = 2647). Associations between HED and DSH were obtained ...

BACKGROUND Alcohol is a significant risk factor for injuries. This study addresses 1) whether the risk of alcohol related injury increases with frequency of heavy episodic drinking (HED) in a linear fashion, and 2) whether a small group of high risk drinkers accounts for the majority of alcohol related injuries. METHODS We applied a case - control design. Cases were BAC positive injured patie...