using complement fixation technique, serial serum samples from 15 patients undergoing surgical removal of malignant tumors were assayed for the presence of tumors antibodies against the cellular fractions of both normal and carcinomatous tissue. antibody responses against tumor associated antigens were detected in four cases. in all cases antibody activity was directed only against the supernat...

STRONG EVIDENCE has accumulated to indicate that erythropoiesis in mammals is under the control of a circulating principle, the erythropoiesisstimulating factor ( ESF ) or erythropoietin.1’2 A similar regulatory system may be operative in amphibians and birds.3’4 The ESF appears in large quantities in the plasma of animals subjected to bleeding or low oxygen pressures’ and its production is inh...

Sera from patients with heart disease were examined by single sandwich indirect immunofluorescence for the presence of antibodies to human heart muscle. Endocardial biopsy specimens were also examined by direct immunofluorescence for deposition of antibodies in vivo. No consistent or specific abnormality was found in the biopsy specimens or sera of patients with congestive cardiomyopathy. The p...

1. In the higher animals control of the functions of the body is dual, being partly neural and partly humoral. 2. When the control of any function is single and not dual, it is entirely neural. Exceptions to this statement appear to occur in connexion with the secretion of urine and milk, since these functions have not hitherto been shown to be under direct neural control. The mamma, and perhap...

Thein vitro s tudy of the combined effects of humoral antibody and lymphocytes has been essential in attempting to understand the paradoxical effect of humoral antibodies leading to the phenomenon of enhancement (1). Par t of the mechanism has been considered to be the shielding of cellular antigenic determinants by humoral antibody from the lymphocytes. This could mask antigenic sites preventi...

From experimental work to determine the role of humoral and cell-mediated responses in the pathogenesis of syphilis evidence has been collected to indicate that both humoral and cell-mediated immunity have a protective function in syphilis.