نتایج جستجو برای: hydroxylation

تعداد نتایج: 6225  

Journal: :Biochemical pharmacology 2005
Tina M Bland Robert L Haining Timothy S Tracy Patrick S Callery

Delta9-tetrahydrocannabinol (delta9-THC), the primary psychoactive constituent of marijuana, is subject to first pass hepatic metabolism primarily by hydroxylation to yield active and inactive oxygenated products. The primary metabolite is formed via oxidation of the allylic methyl group to yield 11-hydroxy-delta9-THC, which is oxidized further to 11-nor-9-carboxy-delta9-THC. The hydroxylation ...

Journal: :Development 2012
Lital Bentovim Roy Amarilio Elazar Zelzer

Collagen production is fundamental for the ontogeny and the phylogeny of all multicellular organisms. It depends on hydroxylation of proline residues, a reaction that uses molecular oxygen as a substrate. This dependency is expected to limit collagen production to oxygenated cells. However, during embryogenesis, cells in different tissues that develop under low oxygen levels must produce this e...

2005
SIDNEY UDENFRIEND

Two 36-amino acid-containing peptides (al-CBZ), isolated from rat skin and tendon collagen by cleavage of the al chain with CNBr, were subjected to enzymatic hydroxylation with collagen proline hydroxylase. The peptides dithered initially only in that the ratio of hydroxyproline to proline was considerably lower in the tendon peptide, although the imino acid content of the two peptides was the ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1997
L Y Lin E W Di Stefano D A Schmitz L Hsu S W Ellis M S Lennard G T Tucker A K Cho

Methamphetamine (MeAmp) abuse has recently experienced a resurgence and approaches to the treatment of its addiction similar to those used with cocaine have been considered. As the treatment regimes are likely to use drugs whose metabolism is related to that of MeAmp, studies were initiated to establish the enzymology of the fate of MeAmp. This report describes investigations of the role of CYP...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1997
B Clement M Demesmaeker

The in vitro N-hydroxylation of guanabenz as well as the corresponding N-dehydroxylation of guanoxabenz has been previously detected in biotransformation studies with microsomal fractions of different species including human hepatic microsomes. Furthermore, the N-hydroxylation of guanabenz was found to be catalyzed by enriched cytochrome P450 (P450) fractions in reconstituted systems. Strong co...

Journal: :Environmental toxicology and pharmacology 1997
Y Maeda K Morita T Tasaki A Kazusaka S Imaoka Y Funae S Fujita

This study examines strain differences in testosterone (T)-hydroxylations between Wistar and Dark Agouti (DA) rats of both genders. The DA rat, an animal model, is a poor metabolizer of such drugs as debrisoquine, which are metabolized by cytochrome P450 (CYP) 2D. T-16α-, 2α-hydroxylations, which are linked to CYP2C11, were catalyzed at similar rates by the microsomes of both strains. In contra...

Journal: :Chemical communications 2015
Yi Yang Yu Tse Chi Hui Hung Toh Zhi Li

Directed evolution of P450pyr created I83M/I82T mutant for highly regioselective terminal hydroxylation of n-butanol to 1,4-butanediol, representing the first achievement of this hydroxylation reaction by chemical or enzymatic methods and an unique example of evolving a hydroxylase to switch the substrate acceptance from a hydrophobic to hydrophilic compound.

2013
A. K. Batta

To examine the defect in side-cbain oxidation during the formation of bile acids in cerebrotendinous xanthomatosis, we measured in vitro hepatic microsomal hydroxylations at C-12 and C-25 and mitochondrial hydroxylation at C-26 and related them to the pool size and synthesis rates of cholic acid and chenodeoxycholic acid as determined by the isotope dilution technique. Hepatic microsomes and mi...

Journal: :Journal of the agricultural chemical society of Japan 1940

Journal: :Applied and Environmental Microbiology 1987

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