Rosita VakiliFaezeh SabetSanaz AahmadiReza BoostaniHoushang RafatpanahAli ShamsianS. A. Rahim Rezaee
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective(s): HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the most common neurological manifestation of HTLV-I. The northeast of Iran is an endem-ic area for this virus. Host genetic and viral factors play important roles in developing HAM/TSP. T...
M NagaiK UsukuW MatsumotoD KodamaN TakenouchiT MoritoyoS HashiguchiM IchinoseC R BanghamS IzumoM Osame
In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitative PCR method using a dual-labeled fluorogenic probe (ABI PRISM 7700 Sequence...
:Proceedings of the National Academy of Sciences1999
K . J . M . J e f f e r y K . U s u k u S . E . H a l l W . M a t s u m o t o G . P . T a y l o r J . P r o c t e r M . B u n c e G . S . O g g K . I . W e l s h J . N . W e b e r A . L . L l o y d M . A . N o w a k M . N a g a i D . K o d a m a S . I z u m o M . O s a m e C . R . M . B a n g h a m
:Proceedings of the National Academy of Sciences of the United States of America1999
K J JefferyK UsukuS E HallW MatsumotoG P TaylorJ ProcterM BunceG S OggK I WelshJ N WeberA L LloydM A NowakM NagaiD KodamaS IzumoM OsameC R Bangham
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is not known whether a persistent class I HLA-restricted antiviral cytotoxic T lymphocyte (CTL) response reduces viral load and is therefore beneficial or causes tissue damage and contributes to disease ...
S MoriA MizoguchiM KawabataH FukunagaK UsukuI MaruyamaM Osame
A study was undertaken to investigate the pathogenesis of pulmonary involvement in human T lymphotropic virus type I (HTLV-I) carriers.
The bronchoalveolar lavage (BAL) cell profile of 30 HTLV-I carriers (15 asymptomatic HTLV-I carriers (AHCs) and 15 symptomatic HTLV-I carriers (SHCs)) with chronic inflammatory diseases of respiratory tract and eight patients with HTLV-I as...
Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated. Materials and...