Interleukin-36 has been implicated in the pathogenesis of various skin disorders. We previously reported that Il36rn-/- mice revealed delayed wound healing due to excessive recruitment immune cells. In this study, we examined effect dimethyl fumarate (DMF), which is an modulator and inducer antioxidant response, for mice. Full-thickness excisional wounds were produced on back wild was assessed ...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...

bakground: multiple sclerosis (ms) is a cd4+ t cell-mediated autoimmune disease affecting the central nervous system (cns). it was previously believed that th1 cells were pathogenic t cells in experimental autoimmune encephalomyelitis (eae). however, the functional role of th1 cells in eae has been reconsidered upon the discovery of il-17- producing t cells which are consider as dominant effect...

background: astrocytes, which comprise ~90% of overall brain mass, are involved in brain immunity. these cells represent the non-professional class of cns-resident apcs and may promote or inhibit cns inflammation depending on the cytokines they secrete. il-10 family of cytokines and their receptors, il-20r1 and il-20r2, may have a role in shifting astrocytes to a neuroprotective or neurodegener...

I will focus on arguments against classical deductive and inductive logic (“relevantist” and “grue” arguments). The talk is mainly defensive. I won’t offer positive accounts of the “paradoxical” cases I will discuss (but, see “Extras”). I’ll begin with Harman’s defense of classical deductive logic against certain (epistemological) “relevantist” arguments. Then, I’ll argue that if you like Harma...