brain death is associated with increased inflammatory cytokines levels and poor graft quality to transplant. we aimed to evaluate the impact of ascorbic acid (aa) on the inflammatory status of brain-dead donors (bdds). forty bdds were randomly divided into two groups. donor treatment (n=20) consisted of 100 mg/kg aa infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6...

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

this study aimed to identify the relationship between fractional exhaled nitric oxide (feno) level and potential factors in non-asthmatic children from shanghai, china. from march to april 2012, the school-aged children fulfilling the inclusion criteria were recruited. the feno levels of non-asthmatic children were detected by the nano coulomb nitric oxide analyzer. questionnaires were recorded...

objective(s): gastroesophageal reflux disease (gerd) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. in the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspiratio...

objective(s) alzheimer’s disease (ad) is a complex disease with multifactorial etiology. inflammation has been proven to have an important role in the pathogenesis of ad. both ccr2 and ccr5 genes expression increase in ad patients comparing to control subjects. ccr5 gene encodes a protein which is a member of the beta chemokine receptors family of integral membrane proteins. ccr5-δ32 is a genet...

background: brown rice (br) is unpolished rice with various beneficial compounds such as vitamins, magnesium and other minerals, dietary fiber, essential fatty acids, γ‑oryzanol and γ‑aminobutyric acid. in the present study, we compared the effects of white rice (wr) and br on inflammatory marker high‑sensitivity c‑reactive protein (hs‑crp) and cardiovascular risk factors among non‑menopausal o...

background: endometriosis is defined as the existence of endometrial-like tissue outside the uterus. diagnosis of endometriosis is a challenging theme. despite the broad search for innovative laboratory tests and advances in imaging technologies, there are still no easy, non-invasive diagnostic tests available. due to inflammatory process of endometriosis, still c-reactive protein (crp) level m...

background and objectives: many nepeta species have been commonly used in iranian folk medicine as tranquilizer, relaxant, carminative and restorative tonic for nervous and respiratory disorders. inflammation is a problem in many diseases and has an important role in brain function that can cause neurodegenerative disorders. inflamed glial cells can exacerbate neurodegenerative diseases by prod...

objective: the aim of this study was to determine the protective effects of coriandrum sativum on acetic acid-inducedcolitis in rats. c. sativum (coriander) has long been used in iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations.  materials and methods: colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fa...

introduction: it has been shown that the extract of elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. the aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (cox) type 1...