conclusions we identified a strong association between the t allele of il6r gene polymorphisms (rs2229238, rs4845625) and the risk of t2d in a protective role and as a risk factor, respectively. we also found different bmi and hdl values between the patient group and the control group, respectively in compare genotypes (ct+tt vs. cc). further studies on various ethnicities are necessary to veri...

physical fitness has an inverse correlation with systemic inflammation. this essence show that anti inflammatory effects of physical activity my explain some of its beneficial influences on body systems. then, regarding to the effects of physical training on biochemical and physiological aspects in human, this present study attempted to investigate the effect of resistance training on some of s...

patients with limbic encephalitis usually present with new onset mesial temporal lobe seizures, progressive memory disturbance, and a variety of other behavioral, emotional, and cognitive changes. autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activ...

background and aims: adenovector gene transfer induces inflammatory response that finally leads to vector removal from delivered site. the effect of hydrodynamic pre-injection on adenovector mediated liver inflammation remained elusive. materials and methods: different mice groups were pre-treated by hydrodynamic saline, dexamethasone or nothing prior to adeno-luciferase administration. their s...

objective(s) air pouch is a well-established inflammatory model in which fluid extravasations; leukocyte migration, angiogenesis and other parameters involved in the inflammatory response can be measured. in this study, the influence of gender on inflammatory parameters has been examined in the air pouch model. materials and methods to induce air pouch, adult male and female wistar rats were an...

background: endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. the present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. materials and me...

background: oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. the administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. the present study aimed to evaluate the radioprotective efficacy o...

background: despite the ever-increasing beneficial applications of magnetic nanoparticles in biological systems, few studies have been carried out on the combined effects of nanoparticles (fe and ni) on human health. in the present study the effects of fe2nio4 nanoparticle on inflammatory factors were assessed. methods : twenty-four wistar rats were randomly divided into 3 groups: two groups we...

introduction: stress is defined as any environmental change that disturbs the maintenance of brain homeostasis. stress leads to production of pro-inflammatory cytokines that provoke neurodegenerative disorders. in the present study, we investigated the effects of dalteparin on hippocampal neuronal death induced by chronic stress in rats. methods: the study was carried out on 60 adult male wista...