Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...

Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then induced focal cerebral ischem...

PURPOSE Retinal ischemia may provoke blindness. There is no effective treatment against retinal ischemic damage. The authors investigated whether brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina from ischemia-reperfusion damage. METHODS Ischemia was induced by increasing intraocular pressure (120 mm Hg for 40 or 60 minutes). Five...

BACKGROUND Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats. METHODS Twenty-four ...

Objective(s): To study the effect of acute and repeated stress on cardioprotection-induced by remote ischemic preconditioning (RIPC).Materials and Methods: RIPC was induced by giving 4 short cycles of ischemia and reperfusion, each consisting of five min. The Langendorff’s apparatus was used to perfuse the isolated rat hearts by subjecti...

Objective- This study investigated the effect of amlodipine on intestinal ischemia-reperfusion injury in ratsDesign-Experimental studyAnimals-Fifteen male Sprague-Dawly rats weighing 200-220gProcedure- Rats were randomly divided into 3 groups: IR group (operation with clamping), sham group (operation without clamping), and IRA group (operation with clamping and 5mg/kg amlodipi...

Lee, H. Thomas, and Charles W. Emala. Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A1 and A3 receptors. Am. J. Physiol. Renal Physiol. 278: F380–F387, 2000.—Renal ischemia and reperfusion during aortic and renal transplant surgery result in ischemic-reperfusion injury. Ischemic preconditioning and adenosine infusion before ischemia protect against isc...

HEADINGS Ischemia/surgery. Reperfusion injury. Liver/surgery. Apoptosis ABSTRACT Background The control of bleeding in hepatectomy is a challenge for surgeons. The hepatic pedicle clamping is a surgical maneuver that can provide reduction in bleeding, but it provokes a hepatocellular suffering. This, along with reperfusion after the clamping finishes, leads to an injury known as ischemia/reperf...

BACKGROUND Free radical injury contributes to cardiac dysfunction during ischemia-reperfusion. Detoxification of free radicals requires maintenance of reduced glutathione (GSH) by NADPH. The principal mechanism responsible for generating NADPH and maintaining GSH during periods of myocardial ischemia-reperfusion remains unknown. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme...