BACKGROUND/AIMS Mesenteric ischemia/reperfusion injury induces a systemic response and releases harmful substances that may affect distant organs such as the lung, liver and kidney. We designed this study to determine if curcumin has protective effects against mesenteric ischemia/reperfusion injury and mesenteric ischemia/reperfusion-induced intestinal and distant organ injury. METHODS Forty ...

This study was designed to elucidate the role of peroxisome proliferator-activated receptor (PPAR)-alpha in the development of inflammation after ischemia/reperfusion injury of the kidney. We have evaluated the effects of ischemia/reperfusion on renal dysfunction, injury, and inflammation in wild-type mice or mice in which the gene for PPAR-alpha has been deleted [PPAR-alpha(-/-)] and then trea...

Aim: Our aim was to investigate expression level of VEGF in tuba uterine ovarian ischemia-reperfusion (I/R) by immunohistochemical techniques. Material and Methods: 30 Sprague Dawley female rats were categorized into three groups. Sham group: The abdomen opened closed without any treatment. Ischemia (I) 1-hour ischemia allowed create ischemic injury. Ischemia-reperfusion then 3-hour reperfusion...

Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...

objective(s):global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in ca1 region of hippocampus. in this study, we investigated the possible neuroprotective effects of the ethanol extract of cyperus rotundus (eecr) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. materials and methods: treatment ...

global cerebral ischemia (gci) and reperfusion induced apoptosis that lead to cell injury and death. the bax and bcl-2 are pro-apoptotic and anti-apoptotic genes, respectively. these genes belong to the b-cell lymphoma-2 (bcl-2) family.in this study; we assessed the effect of pentoxifylline drug on bax/bcl2 gene dosage expression changes following   ischemic reperfusion injury in kidney. in thi...

objective(s):there are a few previously reported studies about the effect of nigella sativa oil on renal ischemia-reperfusion injury (iri). the aim of the present study was to test the hypothesis whether pre- or post-treatment with n. sativa hydroalcoholic extract (nse) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal iri.    materials and methods: ir...

Objective(s):There are a few previously reported studies about the effect of Nigella sativa oil on renal ischemia-reperfusion injury (IRI). The aim of the present study was to test the hypothesis whether pre- or post-treatment with N. sativa hydroalcoholic extract (NSE) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal IRI.    Materials and Methods: IR...

INTRODUCTION Some publications have demonstrated the presence of lung reperfusion injury in mesenteric ischemia and reperfusion (I/R), but under to diverse methods. Postconditioning has been recognized as effective in preventing reperfusion injury in various organs and tissues. However, its effectiveness has not been evaluated in the prevention of lung reperfusion injury after mesenteric ischem...