hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. we report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. she was referred to our center with a chief complaint of abdominal pain. computed tomography scan of the ab...

Increased dietary fat intake in general, and saturated fat specifically, will lead to the impairment of insulin action. The aim of this study was to find out the changes in hepatic glucose output in dependence of fat diet and a possible direct action of insulin and trogitazone in hepatocytes. Hepatocytes were isolated by a collagenase perfusion technique and cultured for 24 h in M 199 serum-fre...

E-mail address: janet.fricker@te 1574-7891/$ – see front matter doi:10.1016/j.molonc.2009.03.003 Taking a ‘‘helicopter view of oncology’’ has become the mainroleof Alexander Eggermont, the first president of the newly reformed European CanCer Organisation (ECCO), who is the driving force behind a new initiative to provide European governments with a ‘‘rationale’’ voice on oncology. But Eggermon...

BACKGROUND Critical limb ischemia portends a risk of major amputation of 25% to 35% within 1 year of diagnosis. Preclinical studies provide evidence that intramuscular injection of autologous CD34+ cells improves limb perfusion and reduces amputation risk. In this randomized, double-blind, placebo-controlled pilot study, we evaluated the safety and efficacy of intramuscular injections of autolo...

The metlhodls usedl for perftusinig isolatedi renal tul)ules are generally clifferent from microptuncture, as are the prob)lems encounteredl. Altlhotuglh I will concentrate maiinly on the teclhnical aslpects of perfuision, it seems to me most important to evaluate to wlhat extent the restults are p)ertinent to the stt(ly of kidney function. Are the tubules still "alive?' Are they still fuinctio...

INTRODUCTION Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Although hepatic granulomas occur in 50-65% of patients with systemic sarcoidosis, isolated liver sarcoidosis is rare. Clinical presentation varies from asymptomatic to manifest. The diagnosis is based on a characteristic histopathological finding of liver biopsy. CASE REPORT We reported a 69-year old man was...

A case in which hepatic artery perfusion scintigraphy (HAPS) correctly predicted the outcome of chemotherapy in a patient with metastatic liver disease is presented. In spite of angiography showing "proper" position of the Infusaid catheter, HAPS showed preferential perfusion to the right lobe of the liver. Computed tomography pre- and postchemotherapy showed a changing pattern of the metastati...

BACKGROUND In this animal study, we evaluated a modified pancreas perfusion method to improve the quality of harvested pancreas in rats. In this model, the portal vein was used as the outflow route during the pancreas perfusion. METHODS Forty-eight male Wistar rats were randomly divided into study group and control group, with 24 rats in each group. In the study group, the portal vein was use...

Hepatic tuberculosis is usually associated with an active pulmonary or miliary tuberculosis, but rarely localizes as a liver tumor mass. The clinical presentation of isolated liver tuberculosis is so rare and atypical that it challenges the clinical acumen of the treating physician. Diagnostic modalities like ultrasound and computed tomography can miss the diagnosis. Ultimately, the diagnosis i...