Optimal seeding in balanced knockout tournaments has only been studied in very limited settings, for example, maximizing predictive power for up to 8 players using only the relative ranking of the players (ordinal information). We broaden the scope of the analysis along several dimensions: tournaments of size up to 128, different player models, ordinal as well as cardinal solutions, and two add...

Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions. Monoamine transporters remove monoamines from the synaptic cleft and thus influence the degree and duration of signaling. Abnormal concentrations of these neuronal transmitters are implicated in a number of neuro...

OBJECTIVE Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death. Here, we examine effects of SR-BI deficiency on cardiovascular phenotypes in low-density lipoprot...

Mutations in succinate dehydrogenase B (SDHB) gene are frequently observed in several tumors and associated with poor prognosis in these tumors. Therefore, drugs effective for SDHB-deficient tumors could fulfill an unmet medical need. In addition, such drugs would have an advantage in that selection of patients with SDHB-mutant cancer could increase the probability of success in clinical trials...

Protein phosphatase 1 plays a major role in the governance of excitatory synaptic activity, and is subject to control via the neuromodulatory actions of dopamine. Mechanisms involved in regulating protein phosphatase 1 activity include interactions with the structurally related cytoskeletal elements spinophilin and neurabin, synaptic scaffolding proteins that are highly enriched in dendritic sp...

CD146 is an endothelial junctional adhesion molecule, which expression increased in human glomerular diseases. However, the pathological significance of this overexpression remains unknown. Induction glomerulonephritis mice, by using nephrotoxic serum, showed that was highly induced within damaged glomeruli and associated with renal inflammation fibrosis. Interestingly, 2 weeks after induction,...