نتایج جستجو برای: knockout
تعداد نتایج: 35497 فیلتر نتایج به سال:
Recent studies revealed C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of endochondral bone growth. As they exist ubiquitously in body, we investigated the physiological role of the local CNP/GC-B in the growth plate on bone growth using cartilage-specific knockout mice. Bones were severely shorter in cartilage-specific CNP or GC-B knockout m...
The importance of bone morphogenetic protein 2 (BMP2) in the skeleton is well known. BMP2 is expressed in a variety of tissues during development, growth and healing. In this study we sought to better identify the role of tissue-specific BMP2 during post-natal growth and to determine if BMP2 knockout affects the ability of terminally differentiated cells to create high quality bone material. We...
Transgenic mice with both alleles of the p53 tumor suppressor gene (frequently mutated in human tumors) knocked out by gene targeting provide a potentially useful tumorigenesis model because these mice rapidly develop spontaneous tumors. To determine whether tumorigenesis in p53-knockout mice is sensitive to experimental manipulation, tumor development in response to calorie restriction (CR; a ...
Recent advances in the description of electromagnetic two-nucleon knockout reactions are reviewed. The sensitivity to different types of correlations and to their treatment in the nuclear wave functions, the effects of final-state interactions and the role of center-of-mass effects in connection with the problem of the lack of orthogonality between initial bound states and final scattering stat...
Reactions that involve the direct and sudden removal of a pair of like or unlike nucleons from a fast projectile beam by a light target nucleus are considered. Specifically, we study the three two-nucleon removal channels from 12C that populate final states in the 10Be, 10B, and 10C reaction residues. The calculated two-nucleon removal cross sections and the residue momentum distributions are c...
Parkinson's disease (PD) is one of the most prevalent neurodegenerative brain diseases; it is accompanied by extensive loss of dopamine (DA) neurons of the substantia nigra that project to the putamen, leading to impaired motor functions. Several genes have been associated with hereditary forms of the disease and transgenic mice have been developed by a number of groups to produce animal models...
Two of the eight constructs (the triple-knockout 3K0 and S1) were well fit by the diffusion model yielding estimates for D. These are listed as Deff in Table I since the estimated D values are too slow to be explained by free diffusion, and so instead reflect the process of effective diffusion whereby fast binding interactions combine with free diffusion to mimic a slowed diffusion (Sprague et ...
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and...
We investigated the interactions of the anticancer drug vinorelbine with drug efflux transporters and cytochrome P450 3A drug-metabolizing enzymes. Vinorelbine was transported by human multidrug-resistance associated protein (MRP) 2, and Mrp2 knockout mice displayed increased vinorelbine plasma exposure after oral administration, suggesting that Mrp2 limits the intestinal uptake of vinorelbine....
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