Administration of chloroquine o r 4,4'-bis(diethylaminoethoxy)a,P-diethyldiphenylethane (DH) to rats in oral doses of 100 mg/kg for 7 days causes phospholipid and cholesteryl ester accumulation i n liver. T o further characterize this drug-induced lipidosis, we have isolated and characterized the lipids of subcellular fractions from control rats and rats treated with chloroquine, DH, and Triton...

Human fibroblasts in culture take up exogenous [choline-Me-3H,32P]sphingomyelin (SM) from the medium and incorporate it into cellular SM and phosphatidylcholine [Spence, Clarke & Cook (1983) J. Biol. Chem. 258, 8595-8600]. The ratio of [3H]choline/[32P]Pi is similar in SM and phosphatidylcholine, indicating that the phosphocholine (P-Cho) moiety is transferred intact. Similar results are obtain...

Apolipoprotein E deficiency (ApoE(-/-)) combined with a high-fat Western-type diet (WD) is known to activate the toll-like receptor (TLR4) pathway and promote atherosclerosis. However, to date, the pathogenic effects of these conditions on the lung have not been extensively studied. Therefore, the present study examined the effects of ApoE(-/-) and a WD on lung injury and investigated the under...

Intravitreal injection of aminoglycoside antibiotics is known to induce morphological changes in the retinal pigment epithelium (RPE) resembling a lipidosis. The RPE of netilmicin-treated rabbits displays a dose-related increase in autofluorescence compared to untreated controls. Netilmicin produces an accumulation of membrane-limited osmiophilic lamellated inclusions in the pigment epithelial ...

Background Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) commonly involve the cardiovascular system and are associated with significant morbidity and mortality, driven by cardiovascular inflammation, microvascular and diastolic dysfunction and fibrosis. Cardiovascular magnetic resonance (CMR) can assess non-invasively cardiac function, strain, ischaemia, altered vascular func...

an adult common mynah ( acridotheres tristis ) was presented with severe signs of progressive depression , anorexia , debilitation , and also a history of moderate pododermatitis for the last two months . hepatomegally was diagnosed clinically and radio-logically . the bird died a couple of hours after referral . postmortem examination revealed typical liver enlargement with yellowish brown dis...

The effect of tricyclic antidepressants (TCA) on phospholipid bilayer structure and dynamics was studied to provide insight into the mechanism of TCA-induced intracellular accumulation of lipids (known as lipidosis). Specifically we asked if the lipid-TCA interaction was TCA or lipid specific and if such physical interactions could contribute to lipidosis. These interactions were probed in mult...

INTRODUCTION A lagille syndrome (ALGS) results from mutations in JAG1 and NOTCH2 in the Notch signaling pathway. These mutations clinically manifest in various ways, but ALGS is most commonly characterized by a paucity of bile ducts in the liver. ALGS often involves the kidney, which can be characterized by defects in the glomerular vasculature, podocytes, proximal tubules, and renal dysplasia....

OKADA, S. & O'BRIEN, J.S. (1968) Generalised gangliosidosis; 1-galactosidase deficiency. Science, Washington, 160, 1002. SACREZ, R., JUIF, J.G., GIGONNET, J.M. & GRUNER, J.E. (1967) La maladie de Landing, ou idiotie amaurotique infantile precoce avec gangliosidose g6neralisee de type GM1. Journe'e de Pidiatrie, 22, 143. ScoTT, C.R., LAGUNOFF, D. & TRUMP, B.F. (1967) Familial neurovisceral lipid...