Hepatic disease is usual in large animals. Increases in serum hepatic enzymes and total bile acid concentration may indicate hepatic dysfunction, insult, disease, or failure. While liver disease is particularlyusual in foals, progression to liver failure isn't.Diseases that frequently result in hepatic failure in horses include Theiler's disease, Tyzzer's disease, pyrrolizidine alkaloid toxicos...
R H Gray,
G A Adam-Rodwell,
J R Haskins,
G D Stoner,
Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 wk. Severe hepatic lipidosis was observed in control rats fed the purified diet...
Robert D. Gordon,
David H. Van Thiel,
Thomas E. Starzl,
A 7-year-old girl with progressive ataxia, spasticity, supranuclear ophthalmoplegia, and sea-blue histiocytes in her bone marrow underwent orthotopic liver transplantation for hepatocellular carcinoma. After an initial period of stabilization, she has shown progression of neurologic symptoms with recurrence of storage material in the transplanted liver. Pediatrics 1986;77:104-106; lipidosis, se...
Metabolic and endocrine characteristics of pregnancy toxemia are well documented in small ruminants, but less known in other species. The objective of this study was to measure plasma levels of certain metabolites and metabolic hormones related to the energetic status in blood from sick and healthy, non-pregnant (control) ferrets. Blood was collected from moribund, hypothermic, late pregnant fe...
S ALTZSTEIN,’ AND LANDING ET AL,2 in 1961 described the occurrence of lipid laden histiocytes in spleens examined in patients with idiopathic thrombocytopenic purpura following splenectomy. These workers suggested that these changes were due to an accumulation of lipids following the ingestion of platelets by the splenic reticuloendothelial system. Similar interpretations have been made by Hill...
Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group. The weight of the heart, liver, kidney, and spleen was less in the treated group while the weight of the lungs was increased significantly. There was no change in the ratio of right ventricular to left ventricular weight in the rats treated with chlorphentermine, support...
:Prostaglandins & other lipid mediators1998
D De Craemer,
C Van den Branden,
We investigated peroxisomal alterations in mice treated with different doses of Lorenzo's Oil (a therapy for X-linked adrenoleukodystrophy patients) for up to 100 days. Hepatic erucic acid levels were already significantly increased 2.2-fold and 2.6-fold in mice treated with 10% and 20% Lorenzo's Oil for 21 days, respectively. No lipidosis was found in liver, myocardium and kidney of any of the...
:Proceedings of the National Academy of Sciences of the United States of America1998
D M Kurtz,
W J Rhead,
D S Millington,
D A Hamm,
A E Brix,
J R Lindsey,
C A Pinkert,
W E O'Brien,
P A Wood,
Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficiency with severely impaired FAO. Matings between LCAD +/- mice yielded an abnormally low number of L...
D J D'Amico,
K R Kenyon,
L A Hanninen,
Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrophages in the subretinal space. These changes were typical of drug-induced lipi...
Intermediate (8--9 nm) filaments of human central nervous system astrocytes were isolated from the gliosed white matter of cases of adrenoleukodystrophy (ALD). This hereditary lipidosis is characterized pathologically by demyelination, loss of axons, and replacement of the white matter of the caudal cerebrum by a glial scar. Glial filaments were composed largely of a single protein component wi...